Protein Summary
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a ma ...more
- ENST00000263238
- ENSP00000263238
- ENSG00000115091
- ARP3
- ARP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
interacting protein | 0.98 | ||
transcription factor binding site profile | 0.94 | ||
disease perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.44 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 299 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.44 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 299 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (299)
ARPC1A
Novelty: 0.07577807
p_int: 0.999524435
p_ni: 0.000475565
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5
Novelty: 0.03434234
p_int: 0.999021034
p_ni: 0.000978966
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR2
Novelty: 0.00731489
p_int: 0.997003372
p_ni: 0.002996628
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3B
Novelty: 0.06033214
p_int: 0.996287125
p_ni: 0.003712875
Score: 0.911
Data Source: BioPlex,STRINGDB
ARPC3
Novelty: 0.02951522
p_int: 0.995471451
p_ni: 0.004528549
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC1B
Novelty: 0.03873325
p_int: 0.991712451
p_ni: 0.008287549
Score: 0.999
Data Source: BioPlex,STRINGDB
CST1
Novelty: 0.02399609
p_int: 0.989999487
p_ni: 0.008920251
p_wrong: 0.001080263
Data Source: BioPlex
CST4
Novelty: 0.00773554
p_int: 0.959561907
p_ni: 0.037895548
p_wrong: 0.002542545
Data Source: BioPlex
ARPC2
Novelty: 0.02478791
p_int: 0.949399347
p_ni: 0.050600653
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5L
Novelty: 0.35566409
p_int: 0.896581186
p_ni: 0.103418814
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (15)
KEGG (2)
PathwayCommons (6)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHB-mediated forward signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Clathrin-mediated endocytosis | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHB-mediated forward signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (12)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 4 | 4 | 81.6 | |||||
BMI-adjusted waist circumference | 1 | 3 | 3 | 64 | |||||
waist-hip ratio | 1 | 4 | 4 | 61.8 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 0 | 7.4 | 59 | ||||
waist circumference | 1 | 3 | 3 | 50.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 81.6 | |||||
BMI-adjusted waist circumference | 3 | 64 | |||||
waist-hip ratio | 4 | 61.8 | |||||
serum alanine aminotransferase measurement | 0 | 7.4 | 59 | ||||
waist circumference | 3 | 50.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | ARP3 actin related protein 3 homolog | 709836 | ||||||
Mouse | MGI:1921367 | 74117 | ||||||
Rat | RGD:71024 | 81732 | ||||||
Dog | ARP3 actin related protein 3 homolog B | VGNC:49707 | 475549 | |||||
Horse | ARP3 actin related protein 3 homolog | VGNC:49331 | 100033909 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | ARP3 actin related protein 3 homolog | |||||
Mouse | ||||||
Rat | ||||||
Dog | ARP3 actin related protein 3 homolog B | |||||
Horse | ARP3 actin related protein 3 homolog | |||||
Publication Statistics
PubMed Score 42.44
PubMed score by year
PubTator Score 179.29
PubTator score by year
Related Publications
Text Mined References (85)
GeneRif Annotations (46)
Items per page:
0 of 0
PMID | Year | Title |
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