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Tchem
ACTR3
Actin-related protein 3

Protein Summary
Description
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263238
  • ENSP00000263238
  • ENSG00000115091

Symbol
  • ARP3
  • ARP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
interacting protein
0.98
transcription factor binding site profile
0.94
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.44   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.44   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.999524435
p_ni:  0.000475565
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
p_int:  0.999021034
p_ni:  0.000978966
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
p_int:  0.997003372
p_ni:  0.002996628
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.996287125
p_ni:  0.003712875
Score:  0.911
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.995471451
p_ni:  0.004528549
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC1B
Tbio
Novelty:  0.03873325
p_int:  0.991712451
p_ni:  0.008287549
Score:  0.999
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.989999487
p_ni:  0.008920251
p_wrong:  0.001080263
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.959561907
p_ni:  0.037895548
p_wrong:  0.002542545
Data Source:  BioPlex
ARPC2
Tbio
Novelty:  0.02478791
p_int:  0.949399347
p_ni:  0.050600653
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC5L
Tdark
Novelty:  0.35566409
p_int:  0.896581186
p_ni:  0.103418814
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
4
4
81.6
BMI-adjusted waist circumference
1
3
3
64
waist-hip ratio
1
4
4
61.8
serum alanine aminotransferase measurement
1
1
0
7.4
59
waist circumference
1
3
3
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
81.6
BMI-adjusted waist circumference
3
64
waist-hip ratio
4
61.8
serum alanine aminotransferase measurement
0
7.4
59
waist circumference
3
50.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ARP3 actin related protein 3 homolog
709836
Mouse
MGI:1921367
74117
Rat
RGD:71024
81732
Dog
ARP3 actin related protein 3 homolog B
VGNC:49707
475549
Horse
ARP3 actin related protein 3 homolog
VGNC:49331
100033909
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ARP3 actin related protein 3 homolog
Mouse
Rat
Dog
ARP3 actin related protein 3 homolog B
Horse
ARP3 actin related protein 3 homolog
Publication Statistics
PubMed Score 42.44
PubMed score by year
PubTator Score 179.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title