Tchem ACTR3 Actin-related protein 3

Protein Summary

Description

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• P61158
• P32391
• Q53QM2

Gene Name

• ACTR3

Ensembl ID

• ENST00000263238
• ENSP00000263238
• ENSG00000115091

Symbol

• ARP3
• ARP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
interacting protein	0.98
transcription factor binding site profile	0.94
disease perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin-related Protein 3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin-related Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.44   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 299   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.44   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

cobimetinib

ACTR3Tchem

INHIBITOR pIC50 : 9.05

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (299)

Explore Interacting Targets

1 – 10 of 299

• See Interactions on String-DB

ARPC1A

Tbio

Novelty:  0.07577807

p_int:  0.999524435

p_ni:  0.000475565

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC5

Tbio

Novelty:  0.03434234

p_int:  0.999021034

p_ni:  0.000978966

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR2

Tchem

Novelty:  0.00731489

p_int:  0.997003372

p_ni:  0.002996628

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR3B

Tbio

Novelty:  0.06033214

p_int:  0.996287125

p_ni:  0.003712875

Score:  0.911

Data Source:  BioPlex,STRINGDB

ARPC3

Tbio

Novelty:  0.02951522

p_int:  0.995471451

p_ni:  0.004528549

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC1B

Tbio

Novelty:  0.03873325

p_int:  0.991712451

p_ni:  0.008287549

Score:  0.999

Data Source:  BioPlex,STRINGDB

CST1

Tbio

Novelty:  0.02399609

p_int:  0.989999487

p_ni:  0.008920251

p_wrong:  0.001080263

Data Source:  BioPlex

CST4

Tbio

Novelty:  0.00773554

p_int:  0.959561907

p_ni:  0.037895548

p_wrong:  0.002542545

Data Source:  BioPlex

ARPC2

Tbio

Novelty:  0.02478791

p_int:  0.949399347

p_ni:  0.050600653

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC5L

Tdark

Novelty:  0.35566409

p_int:  0.896581186

p_ni:  0.103418814

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (24)

Reactome (15)

KEGG (2)

PathwayCommons (6)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (3)

Components (12)

Processes (13)

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1 – 3 of 3

GO Term	Evidence	Assigned by
structural constituent of cytoskeleton	Inferred from Direct Assay (IDA)	FlyBase
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (6)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	2	4	4		81.6
BMI-adjusted waist circumference	EFO_0007789	1	3	3		64
waist-hip ratio	EFO_0004343	1	4	4		61.8
serum alanine aminotransferase measurement	EFO_0004735	1	1	0	7.4	59
waist circumference	EFO_0004342	1	3	3		50.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	4		81.6
BMI-adjusted waist circumference	EFO_0007789	3		64
waist-hip ratio	EFO_0004343	4		61.8
serum alanine aminotransferase measurement	EFO_0004735	0	7.4	59
waist circumference	EFO_0004342	3		50.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
ATP-binding
Cell projection
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
serum alanine aminotransferase measurement
sex hormone-binding globulin measurement
waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ARP3 actin related protein 3 homolog		709836
Mouse	ARP3 actin-related protein 3	MGI:1921367	74117
Rat	ARP3 actin related protein 3 homolog	RGD:71024	81732
Dog	ARP3 actin related protein 3 homolog B	VGNC:49707	475549
Horse	ARP3 actin related protein 3 homolog	VGNC:49331	100033909

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ARP3 actin related protein 3 homolog
Mouse	ARP3 actin-related protein 3
Rat	ARP3 actin related protein 3 homolog
Dog	ARP3 actin related protein 3 homolog B
Horse	ARP3 actin related protein 3 homolog

Publication Statistics

PubMed Score 42.44

PubMed score by year

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PubTator Score 179.29

PubTator score by year

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Related Publications

Text Mined References (85)

GeneRif Annotations (46)

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PMID	Year	Title