Tchem ACTR2 Actin-related protein 2

Protein Summary

Description

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61160
• B2RCP5
• D6W5F4
• E9PF41
• O15142
• Q96C82

Gene Name

• ACTR2

Ensembl ID

• ENST00000260641
• ENSP00000260641
• ENSG00000138071
• ENST00000377982
• ENSP00000367220

Symbol

• ARP2
• ARP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor perturbation	0.96
molecular function	0.91
disease perturbation	0.87
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin-related Protein 2

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin-related Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.89   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.89   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

talmapimod

ACTR2Tchem

pKd : 8.4

Protein-Protein Interactions (439)

Explore Interacting Targets

1 – 10 of 439

• See Interactions on String-DB

ACTR3B

Tbio

Novelty:  0.06033214

p_int:  0.99988571

p_ni:  0.00011429

Score:  0.984

Data Source:  BioPlex,STRINGDB

ARPC1A

Tbio

Novelty:  0.07577807

p_int:  0.997610987

p_ni:  0.002389013

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR3

Tchem

Novelty:  0.02112745

p_int:  0.997003372

p_ni:  0.002996628

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC1B

Tbio

Novelty:  0.03873325

p_int:  0.996328509

p_ni:  0.003671491

Score:  0.999

Data Source:  BioPlex,STRINGDB

CHURC1

Tbio

Novelty:  0.05885372

p_int:  0.975948134

p_ni:  0.024051866

Data Source:  BioPlex

ARPC3

Tbio

Novelty:  0.02951522

p_int:  0.97525584

p_ni:  0.02474416

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC2

Tbio

Novelty:  0.02478791

Score:  0.999

Data Source:  STRINGDB

ARPC5L

Tdark

Novelty:  0.35566409

Score:  0.999

Data Source:  STRINGDB

ARPC5

Tbio

Novelty:  0.03434234

Score:  0.999

Data Source:  STRINGDB

ARPC4

Tbio

Novelty:  0.04212335

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (47)

Reactome (16)

KEGG (2)

PathwayCommons (10)

WikiPathways (19)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (40)

Functions (3)

Components (17)

Processes (20)

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1 – 3 of 3

GO Term	Evidence	Assigned by
structural constituent of cytoskeleton	Inferred from Direct Assay (IDA)	FlyBase
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	5	3	2	1.1	80.2
self reported educational attainment	EFO_0004784	1	1	1		60.5
tonsillectomy risk measurement	EFO_0007924	1	1	0	1.1	52.7
heel bone mineral density	EFO_0009270	2	2	2		52.4
lung adenocarcinoma	EFO_0000571	1	1	0	1.1	21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	2	1.1	80.2
self reported educational attainment	EFO_0004784	1		60.5
tonsillectomy risk measurement	EFO_0007924	0	1.1	52.7
heel bone mineral density	EFO_0009270	2		52.4
lung adenocarcinoma	EFO_0000571	0	1.1	21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Alternative splicing
ATP-binding
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
coronary artery disease
heel bone mineral density
lung adenocarcinoma
mean platelet volume
rheumatoid arthritis
self reported educational attainment
tonsillectomy risk measurement

IDG Resources

No IDG generated resources found

Orthologs (18)

1 – 5 of 18

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ARP2 actin related protein 2 homolog		746973
Macaque	ARP2 actin related protein 2 homolog		697080
Mouse	ARP2 actin-related protein 2	MGI:1913963	66713
Rat	ARP2 actin related protein 2 homolog	RGD:1310826	289820
Dog	ARP2 actin related protein 2 homolog	VGNC:37554	481396

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ARP2 actin related protein 2 homolog
Macaque	ARP2 actin related protein 2 homolog
Mouse	ARP2 actin-related protein 2
Rat	ARP2 actin related protein 2 homolog
Dog	ARP2 actin related protein 2 homolog

Publication Statistics

PubMed Score 138.89

PubMed score by year

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PubTator Score 667.82

PubTator score by year

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Related Publications

Text Mined References (84)

GeneRif Annotations (45)

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PMID	Year	Title