Protein Summary
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This comp ...more
- ENST00000260641
- ENSP00000260641
- ENSG00000138071
- ENST00000377982
- ENSP00000367220
- ARP2
- ARP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
transcription factor perturbation | 0.96 | ||
molecular function | 0.91 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 138.89 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 138.89 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (439)
ACTR3B
Novelty: 0.06033214
p_int: 0.99988571
p_ni: 0.00011429
Score: 0.984
Data Source: BioPlex,STRINGDB
ARPC1A
Novelty: 0.07577807
p_int: 0.997610987
p_ni: 0.002389013
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3
Novelty: 0.02112745
p_int: 0.997003372
p_ni: 0.002996628
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC1B
Novelty: 0.03873325
p_int: 0.996328509
p_ni: 0.003671491
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC3
Novelty: 0.02951522
p_int: 0.97525584
p_ni: 0.02474416
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (47)
Reactome (16)
KEGG (2)
PathwayCommons (10)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHB-mediated forward signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Clathrin-mediated endocytosis | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHB-mediated forward signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (3)
Components (17)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 3 | 2 | 1.1 | 80.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 60.5 | |||||
tonsillectomy risk measurement | 1 | 1 | 0 | 1.1 | 52.7 | ||||
heel bone mineral density | 2 | 2 | 2 | 52.4 | |||||
1 | 1 | 0 | 1.1 | 21.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 1.1 | 80.2 | |||||
self reported educational attainment | 1 | 60.5 | |||||
tonsillectomy risk measurement | 0 | 1.1 | 52.7 | ||||
heel bone mineral density | 2 | 52.4 | |||||
0 | 1.1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (18)
1 – 5 of 18
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ARP2 actin related protein 2 homolog | 746973 | ||||||
Macaque | ARP2 actin related protein 2 homolog | 697080 | ||||||
Mouse | MGI:1913963 | 66713 | ||||||
Rat | RGD:1310826 | 289820 | ||||||
Dog | ARP2 actin related protein 2 homolog | VGNC:37554 | 481396 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ARP2 actin related protein 2 homolog | |||||
Macaque | ARP2 actin related protein 2 homolog | |||||
Mouse | ||||||
Rat | ||||||
Dog | ARP2 actin related protein 2 homolog | |||||
Publication Statistics
PubMed Score 138.89
PubMed score by year
PubTator Score 667.82
PubTator score by year
Related Publications
Text Mined References (84)
GeneRif Annotations (45)
Items per page:
0 of 0
PMID | Year | Title |
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