Protein Summary
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
- ENST00000369905
- ENSP00000358921
- ENSG00000138107
- CTRN1
- ARP1
- Arp1A
- CTRN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.96 | ||
transcription factor binding site profile | 0.92 | ||
interacting protein | 0.8 | ||
transcription factor perturbation | 0.8 | ||
microRNA | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.46 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.46 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (357)
ACTR10
Novelty: 0.11388846
p_int: 0.999980666
p_ni: 0.000019334
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Novelty: 0.30624393
p_int: 0.999941174
p_ni: 0.000058826
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Novelty: 0.10014723
p_int: 0.999892346
p_ni: 0.000107654
Score: 0.985
Data Source: BioPlex,STRINGDB
DCTN1
Novelty: 0.00494896
p_int: 0.99936814
p_ni: 0.00063186
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN4
Novelty: 0.10319227
p_int: 0.996611013
p_ni: 0.003388987
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Novelty: 0.14551388
p_int: 0.99429513
p_ni: 0.00570487
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Novelty: 0.14014918
p_int: 0.988859226
p_ni: 0.011140775
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Novelty: 0.01045432
p_int: 0.976781778
p_ni: 0.023218223
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Novelty: 0.19530162
p_int: 0.972399563
p_ni: 0.000099797
p_wrong: 0.02750064
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Novelty: 0.07279226
p_int: 0.963986534
p_ni: 0.036013466
Score: 0.554
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (33)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-independent Golgi-to-ER retrograde traffic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Adaptive Immune System | ||||
Anchoring of the basal body to the plasma membrane | ||||
Asparagine N-linked glycosylation | ||||
COPI-independent Golgi-to-ER retrograde traffic | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (1)
Components (12)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1 | 85.6 | |||||
4 | 3 | 2 | 1 | 78.6 | |||||
2 | 2 | 0 | 1.1 | 75 | |||||
leukocyte count | 2 | 2 | 2 | 68.1 | |||||
eosinophil count | 2 | 2 | 2 | 68 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1 | 85.6 | |||||
2 | 1 | 78.6 | |||||
0 | 1.1 | 75 | |||||
leukocyte count | 2 | 68.1 | |||||
eosinophil count | 2 | 68 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ARP1 actin related protein 1 homolog A | VGNC:14557 | 466191 | |||||
Macaque | ARP1 actin related protein 1 homolog A | 713513 | ||||||
Mouse | MGI:1858964 | 54130 | ||||||
Rat | RGD:1307025 | 294010 | ||||||
Dog | ARP1 actin related protein 1 homolog A | VGNC:37552 | 403791 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ARP1 actin related protein 1 homolog A | |||||
Macaque | ARP1 actin related protein 1 homolog A | |||||
Mouse | ||||||
Rat | ||||||
Dog | ARP1 actin related protein 1 homolog A | |||||
Publication Statistics
PubMed Score 14.46
PubMed score by year
PubTator Score 47.31
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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