Tbio ACTR1A Alpha-centractin

Protein Summary

Description

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61163
• B2R6B0
• P42024
• Centractin

Gene Name

• ACTR1A

Ensembl ID

• ENST00000369905
• ENSP00000358921
• ENSG00000138107

Symbol

• CTRN1
• ARP1
• Arp1A
• CTRN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
transcription factor binding site profile	0.92
interacting protein	0.8
transcription factor perturbation	0.8
microRNA	0.76

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Alpha-centractin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Alpha-centractin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (357)

Explore Interacting Targets

1 – 10 of 357

• See Interactions on String-DB

ACTR10

Tbio

Novelty:  0.11388846

p_int:  0.999980666

p_ni:  0.000019334

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

DCTN6

Tdark

Novelty:  0.30624393

p_int:  0.999941174

p_ni:  0.000058826

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACTR1B

Tbio

Novelty:  0.10014723

p_int:  0.999892346

p_ni:  0.000107654

Score:  0.985

Data Source:  BioPlex,STRINGDB

DCTN1

Tbio

Novelty:  0.00494896

p_int:  0.99936814

p_ni:  0.00063186

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

DCTN4

Tbio

Novelty:  0.10319227

p_int:  0.996611013

p_ni:  0.003388987

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

DCTN3

Tbio

Novelty:  0.14551388

p_int:  0.99429513

p_ni:  0.00570487

Score:  0.946

Data Source:  BioPlex,Reactome,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

p_int:  0.988859226

p_ni:  0.011140775

Score:  0.986

Data Source:  BioPlex,Reactome,STRINGDB

DCTN2

Tbio

Novelty:  0.01045432

p_int:  0.976781778

p_ni:  0.023218223

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

DCTN5

Tbio

Novelty:  0.19530162

p_int:  0.972399563

p_ni:  0.000099797

p_wrong:  0.02750064

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

KLHL2

Tbio

Novelty:  0.07279226

p_int:  0.963986534

p_ni:  0.036013466

Score:  0.554

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

Reactome (33)

PathwayCommons (1)

AURKA Activation by TPX2 (R-HSA-8854518)

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5

1 – 5 of 33

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Adaptive Immune System	894 targets	R-HSA-1280218
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (1)

Components (12)

Processes (7)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (27)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergic rhinitis	EFO_0005854	3	3	0	1	85.6
allergy	EFO_0003785	4	3	2	1	78.6
schizophrenia	EFO_0000692	2	2	0	1.1	75
leukocyte count	EFO_0004308	2	2	2		68.1
eosinophil count	EFO_0004842	2	2	2		68

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergic rhinitis	EFO_0005854	0	1	85.6
allergy	EFO_0003785	2	1	78.6
schizophrenia	EFO_0000692	0	1.1	75
leukocyte count	EFO_0004308	2		68.1
eosinophil count	EFO_0004842	2		68

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Nucleotide-binding
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
allergic rhinitis
allergy
apolipoprotein B measurement
asthma
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist circumference
creatinine measurement
Eczema

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ARP1 actin related protein 1 homolog A	VGNC:14557	466191
Macaque	ARP1 actin related protein 1 homolog A		713513
Mouse	ARP1 actin-related protein 1A, centractin alpha	MGI:1858964	54130
Rat	ARP1 actin related protein 1 homolog A	RGD:1307025	294010
Dog	ARP1 actin related protein 1 homolog A	VGNC:37552	403791

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ARP1 actin related protein 1 homolog A
Macaque	ARP1 actin related protein 1 homolog A
Mouse	ARP1 actin-related protein 1A, centractin alpha
Rat	ARP1 actin related protein 1 homolog A
Dog	ARP1 actin related protein 1 homolog A

Publication Statistics

PubMed Score 14.46

PubMed score by year

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PubTator Score 47.31

PubTator score by year

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Related Publications

Text Mined References (38)

GeneRif Annotations (2)

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0 of 0

PMID	Year	Title