You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACTL6A
Actin-like protein 6A

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392662
  • ENSP00000376430
  • ENSG00000136518
  • ENST00000429709
  • ENSP00000397552
  • ENST00000450518
  • ENSP00000394014

Symbol
  • BAF53
  • BAF53A
  • INO80K
  • Arp4
  • ACTL6
  • BAF53A
  • INO80K
  • ARPN-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
hub protein
0.94
molecular function
0.94
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.18   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.18   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (310)
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  0.982302705
p_ni:  0.017697295
Score:  0.901
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.972938314
p_ni:  0.027061686
Score:  0.783
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.963969736
p_ni:  0.036030264
Score:  0.419
Data Source:  BioPlex,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.954909065
p_ni:  0.043682287
p_wrong:  0.001408648
Score:  0.191
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.95420583
p_ni:  0.04579417
Score:  0.997
Data Source:  BioPlex,STRINGDB
HINT1
Tchem
Novelty:  0.00815168
p_int:  0.935954113
p_ni:  0.063962674
p_wrong:  0.000083213
Score:  0.219
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.927423048
p_ni:  0.072576952
Score:  0.973
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.920858529
p_ni:  0.079141401
p_wrong:  7e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
p_int:  0.910419609
p_ni:  0.08958039
p_wrong:  1e-9
Score:  0.394
Data Source:  BioPlex,STRINGDB
CYB5R3
Tbio
Family:  Enzyme
Novelty:  0.00774258
p_int:  0.906905389
p_ni:  0.093094559
p_wrong:  5.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin like 6A
VGNC:5022
460863
Macaque
actin like 6A
708935
Mouse
MGI:1861453
56456
Rat
RGD:1307747
361925
Dog
actin like 6A
VGNC:37542
478637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin like 6A
Macaque
actin like 6A
Mouse
Rat
Dog
actin like 6A
Publication Statistics
PubMed Score 61.18
PubMed score by year
PubTator Score 27.18
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title