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Tbio
ACTG2
Actin, gamma-enteric smooth muscle

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345517
  • ENSP00000295137
  • ENSG00000163017
  • ENST00000409624
  • ENSP00000386857
  • ENST00000409731
  • ENSP00000386929

Symbol
  • ACTA3
  • ACTL3
  • ACTSG
  • ACT
  • ACTE
  • VSCM
  • ACTA3
  • ACTL3
  • ACTSG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
gene perturbation
0.91
PubMedID
0.9
small molecule perturbation
0.85
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.02   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.02   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
TPM2
Tbio
Novelty:  0.00406572
Score:  0.988
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.986
Data Source:  STRINGDB
TPM4
Tbio
Novelty:  0.00557194
Score:  0.986
Data Source:  STRINGDB
TPM1
Tbio
Novelty:  0.00261206
Score:  0.986
Data Source:  STRINGDB
TPM3
Tbio
Novelty:  0.00108151
Score:  0.985
Data Source:  STRINGDB
MYLPF
Tbio
Novelty:  0.00960325
Score:  0.984
Data Source:  STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.969
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.969
Data Source:  STRINGDB
LMOD1
Tbio
Novelty:  0.04769107
Score:  0.966
Data Source:  STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (218)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
3
3
94.4
mitochondrial DNA measurement
2
2
2
93.1
2
2
0
1.3
91.9
lymphocyte count
1
1
1
32.3
creatinine measurement
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
3
94.4
mitochondrial DNA measurement
2
93.1
0
1.3
91.9
lymphocyte count
1
32.3
creatinine measurement
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
actin, gamma 2, smooth muscle, enteric
707447
Mouse
MGI:104589
11468
Rat
RGD:2027
25365
Dog
actin, gamma 2, smooth muscle, enteric
VGNC:37541
475792
Horse
actin, gamma 2, smooth muscle, enteric
VGNC:15016
100057561
Species
Name
OMA
EggNOG
Inparanoid
Macaque
actin, gamma 2, smooth muscle, enteric
Mouse
Rat
Dog
actin, gamma 2, smooth muscle, enteric
Horse
actin, gamma 2, smooth muscle, enteric
Publication Statistics
PubMed Score 360.02
PubMed score by year
PubTator Score 31.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title