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Tbio
ACTB
Actin, cytoplasmic 1

Protein Summary
Description
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331789
  • ENSP00000349960
  • ENSG00000075624
  • ENST00000493945
  • ENSP00000494269
  • ENST00000646664
  • ENSP00000494750

Symbol
  • BRWS1
  • PS1TP5BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
molecular function
1
protein complex
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12328.46   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 1721   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12328.46   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 1721   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (889)
POTEKP
Tdark
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Data Source:  BioPlex
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999999982
p_ni:  1.8e-8
Data Source:  BioPlex
SPIRE1
Tbio
Novelty:  0.04929601
p_int:  0.999999862
p_ni:  1.38e-7
Score:  0.45
Data Source:  BioPlex,STRINGDB
SPIRE2
Tbio
Novelty:  0.06697946
p_int:  0.999999137
p_ni:  8.58e-7
p_wrong:  6e-9
Score:  0.423
Data Source:  BioPlex,STRINGDB
KLHL7
Tbio
Novelty:  0.0522116
p_int:  0.999649249
p_ni:  0.000176517
p_wrong:  0.000174234
Data Source:  BioPlex
LRRC20
Tdark
Novelty:  3.82267008
p_int:  0.999578029
p_ni:  0.000421971
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.999330741
p_ni:  0.000669259
Score:  0.563
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.999201974
p_ni:  0.000798026
Score:  0.946
Data Source:  BioPlex,STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
p_int:  0.998997672
p_ni:  0.001002328
Score:  0.231
Data Source:  BioPlex,STRINGDB
GC
Tchem
Novelty:  0.00065382
p_int:  0.998831261
p_ni:  0.001168739
Score:  0.286
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (173)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Chaperonin-mediated protein folding
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Axon guidance
B-WICH complex positively regulates rRNA expression
Chaperonin-mediated protein folding
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
59
reticulocyte measurement
2
2
2
57.6
educational attainment
1
2
2
54.3
mathematical ability
3
3
3
54.1
reticulocyte count
2
2
2
53.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
59
reticulocyte measurement
2
57.6
educational attainment
2
54.3
mathematical ability
3
54.1
reticulocyte count
2
53.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin beta
VGNC:50814
450133
Mouse
MGI:87904
11461
Rat
RGD:628837
81822
Dog
actin beta
403580
Horse
actin gamma 1
VGNC:51374
100050139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin beta
Mouse
Rat
Dog
actin beta
Horse
actin gamma 1
Publication Statistics
PubMed Score 12328.46
PubMed score by year
PubTator Score 141.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title