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Tbio
ACTA2
Actin, aortic smooth muscle

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224784
  • ENSP00000224784
  • ENSG00000107796

Symbol
  • ACTSA
  • ACTVS
  • ACTSA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
PubMedID
0.96
transcription factor perturbation
0.94
gene perturbation
0.88
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.65   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 1355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.65   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 1355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (353)
ACTA1
Tbio
Novelty:  0.00111813
p_int:  1
Data Source:  BioPlex
POTEKP
Tdark
p_int:  0.999999966
p_ni:  3.4e-8
Data Source:  BioPlex
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
p_int:  0.999973478
p_ni:  0.000026521
Score:  0.177
Data Source:  BioPlex,STRINGDB
LRRC20
Tdark
Novelty:  3.82267008
p_int:  0.999942079
p_ni:  0.000057921
Data Source:  BioPlex
PHACTR2
Tbio
Family:  Enzyme
Novelty:  0.25056698
p_int:  0.999918548
p_ni:  0.000081452
Score:  0.719
Data Source:  BioPlex,STRINGDB
PFN3
Tdark
Novelty:  0.11291078
p_int:  0.999895525
p_ni:  0.000104475
Score:  0.186
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.999771369
p_ni:  0.000228631
Data Source:  BioPlex
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.999691923
p_ni:  0.000308077
Score:  0.386
Data Source:  BioPlex,STRINGDB
THRB
Tclin
Family:  NR
Novelty:  0.0014797
p_int:  0.999448748
p_ni:  0.000551252
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.999330741
p_ni:  0.000669259
Score:  0.563
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
NOTCH4 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH4
Name
Explore in Pharos
Explore in Source
Muscle contraction
NOTCH4 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor superfamily member 6 measurement
1
3
3
96.4
4
3
0
1.3
81.2
blood protein measurement
1
1
1
78.9
lymphocyte percentage of leukocytes
1
1
1
59.9
mean corpuscular volume
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor superfamily member 6 measurement
3
96.4
0
1.3
81.2
blood protein measurement
1
78.9
lymphocyte percentage of leukocytes
1
59.9
mean corpuscular volume
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
actin, alpha 2, smooth muscle, aorta
100427024
Mouse
MGI:87909
11475
Rat
RGD:621676
81633
Dog
actin, alpha 2, smooth muscle, aorta
VGNC:37539
477587
Horse
actin, alpha 2, smooth muscle, aorta
VGNC:15013
100062175
Species
Name
OMA
EggNOG
Inparanoid
Macaque
actin, alpha 2, smooth muscle, aorta
Mouse
Rat
Dog
actin, alpha 2, smooth muscle, aorta
Horse
actin, alpha 2, smooth muscle, aorta
Publication Statistics
PubMed Score 461.65
PubMed score by year
PubTator Score 144.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title