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Tbio
ACSS1
Acetyl-coenzyme A synthetase 2-like, mitochondrial

Protein Summary
Description
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323482
  • ENSP00000316924
  • ENSG00000154930
  • ENST00000432802
  • ENSP00000388793
  • ENST00000537502
  • ENSP00000439304

Symbol
  • ACAS2L
  • KIAA1846
  • ACAS2L
  • ACECS1
  • AceCS2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.93
transcription factor perturbation
0.8
disease perturbation
0.79
PubMedID
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.22   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.22   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999975207
p_ni:  0.000024603
p_wrong:  1.9e-7
Score:  0.563
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.999334761
p_ni:  0.000250995
p_wrong:  0.000414244
Score:  0.738
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.999128437
p_ni:  0.000303177
p_wrong:  0.000568386
Score:  0.347
Data Source:  BioPlex,STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
p_int:  0.999116688
p_ni:  0.000376608
p_wrong:  0.000506704
Score:  0.309
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.823050142
p_ni:  0.000163264
p_wrong:  0.176786594
Data Source:  BioPlex
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
Score:  0.985
Data Source:  STRINGDB
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
Score:  0.959
Data Source:  STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
Score:  0.95
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.945
Data Source:  STRINGDB
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
Score:  0.942
Data Source:  STRINGDB
Pathways (19)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
42.3
C-reactive protein measurement
1
1
1
6.1
gut microbiome measurement
1
1
0
3.5
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
42.3
C-reactive protein measurement
1
6.1
gut microbiome measurement
0
3.5
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 1
VGNC:51749
469905
Macaque
acyl-CoA synthetase short chain family member 1
705060
Mouse
MGI:1915988
68738
Rat
RGD:1306246
296259
Dog
acyl-CoA synthetase short chain family member 1
VGNC:52863
477002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 1
Macaque
acyl-CoA synthetase short chain family member 1
Mouse
Rat
Dog
acyl-CoA synthetase short chain family member 1
Publication Statistics
PubMed Score 41.22
PubMed score by year
PubTator Score 9.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title