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Tbio
ACSL1
Long-chain-fatty-acid--CoA ligase 1

Protein Summary
Description
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281455
  • ENSP00000281455
  • ENSG00000151726
  • ENST00000504342
  • ENSP00000425006
  • ENST00000513317
  • ENSP00000426150
  • ENST00000515030
  • ENSP00000422607

Symbol
  • FACL1
  • FACL2
  • LACS
  • LACS1
  • LACS2
  • ACS1
  • LACS
  • FACL1
  • FACL2
  • LACS1
  • LACS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.96
cellular component
0.92
disease perturbation
0.87
molecular function
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.57   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.57   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.975
Data Source:  STRINGDB
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
Score:  0.968
Data Source:  STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.962
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.961
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.953
Data Source:  STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.952
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.95
Data Source:  STRINGDB
FABP1
Tchem
Novelty:  0.00192691
Score:  0.946
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.931
Data Source:  STRINGDB
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.927
Data Source:  STRINGDB
Pathways (29)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1.1
90
mean platelet volume
2
3
3
84.6
mean reticulocyte volume
1
1
1
48.5
glucose measurement
1
1
1
39.6
age at menopause
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
90
mean platelet volume
3
84.6
mean reticulocyte volume
1
48.5
glucose measurement
1
39.6
age at menopause
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 1
VGNC:550
461631
Macaque
acyl-CoA synthetase long chain family member 1
694871
Mouse
MGI:102797
14081
Rat
RGD:2015
25288
Dog
acyl-CoA synthetase long chain family member 1
VGNC:37532
475631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 1
Macaque
acyl-CoA synthetase long chain family member 1
Mouse
Rat
Dog
acyl-CoA synthetase long chain family member 1
Publication Statistics
PubMed Score 330.57
PubMed score by year
PubTator Score 111.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title