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Tbio
ACSF3
Acyl-CoA synthetase family member 3, mitochondrial

Protein Summary
Description
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates. This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317447
  • ENSP00000320646
  • ENSG00000176715
  • ENST00000406948
  • ENSP00000384627
  • ENST00000614302
  • ENSP00000479130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
tissue sample
0.67
disease perturbation
0.62
kinase perturbation
0.6
transcription factor binding site profile
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999998627
p_ni:  0.000001373
Score:  0.187
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.99797085
p_ni:  0.002029101
p_wrong:  4.9e-8
Data Source:  BioPlex
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.992290749
p_ni:  0.007709247
p_wrong:  4e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.952245786
p_ni:  0.047754214
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.936955934
p_ni:  0.063044066
Score:  0.199
Data Source:  BioPlex,STRINGDB
KCTD14
Tdark
Novelty:  1.19182828
p_int:  0.931690408
p_ni:  0.06830959
p_wrong:  2e-9
Score:  0.622
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.911068258
p_ni:  0.088930292
p_wrong:  0.00000145
Score:  0.489
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.903064474
p_ni:  0.096931754
p_wrong:  0.000003773
Score:  0.19
Data Source:  BioPlex,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.848779658
p_ni:  0.151220342
Score:  0.375
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.825074406
p_ni:  0.174923208
p_wrong:  0.000002386
Score:  0.321
Data Source:  BioPlex,STRINGDB
Pathways (9)
Fatty acid metabolism (R-HSA-8978868)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
3
0
3.4
94.3
suntan
1
1
1
92.2
carotid artery intima media thickness
4
2
4
86.3
aortic measurement
3
2
3
84.9
hair colour measurement
1
7
7
74.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
3.4
94.3
suntan
1
92.2
carotid artery intima media thickness
4
86.3
aortic measurement
3
84.9
hair colour measurement
7
74.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase family member 3
VGNC:51555
454311
Mouse
MGI:2182591
257633
Rat
RGD:1586037
498962
Dog
acyl-CoA synthetase family member 3
VGNC:37531
100683704
Horse
acyl-CoA synthetase family member 3
VGNC:15003
100051639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase family member 3
Mouse
Rat
Dog
acyl-CoA synthetase family member 3
Horse
acyl-CoA synthetase family member 3
Publication Statistics
PubMed Score 28.68
PubMed score by year
PubTator Score 12.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title