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Tbio
ACSBG2
Long-chain-fatty-acid--CoA ligase ACSBG2

Protein Summary
Description
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000586696
  • ENSP00000465589
  • ENSG00000130377
  • ENST00000588304
  • ENSP00000464938
  • ENST00000588485
  • ENSP00000466336
  • ENST00000591403
  • ENSP00000467755

Symbol
  • BGR
  • BGR
  • BRGL
  • PRTDNY3
  • PRTD-NY3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
cell type or tissue
0.63
pathway
0.63
tissue
0.61
cell line
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.905074516
p_ni:  0.094925484
Score:  0.188
Data Source:  BioPlex,STRINGDB
CMSS1
Tdark
Novelty:  0.21418543
p_int:  0.7668129
p_ni:  0.016959812
p_wrong:  0.216227288
Score:  0.403
Data Source:  BioPlex,STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.951
Data Source:  STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.938
Data Source:  STRINGDB
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
Score:  0.936
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.932
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.929
Data Source:  STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.912
Data Source:  STRINGDB
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.906
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.809
Data Source:  STRINGDB
Pathways (33)
Fatty acid metabolism (R-HSA-8978868)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
88.5
monocyte percentage of leukocytes
1
1
1
58.4
heel bone mineral density
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
88.5
monocyte percentage of leukocytes
1
58.4
heel bone mineral density
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
acyl-CoA synthetase bubblegum family member 2
698717
Mouse
MGI:3587728
328845
Rat
RGD:1588580
301120
Dog
acyl-CoA synthetase bubblegum family member 2
VGNC:54569
476732
Horse
acyl-CoA synthetase bubblegum family member 2
VGNC:15001
100065344
Species
Name
OMA
EggNOG
Inparanoid
Macaque
acyl-CoA synthetase bubblegum family member 2
Mouse
Rat
Dog
acyl-CoA synthetase bubblegum family member 2
Horse
acyl-CoA synthetase bubblegum family member 2
Publication Statistics
PubMed Score 10.55
PubMed score by year
PubTator Score 4.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title