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Tbio
ACRV1
Acrosomal protein SP-10

Protein Summary
Description
This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315608
  • ENSP00000317684
  • ENSG00000134940
  • ENST00000527795
  • ENSP00000436819
  • ENST00000530048
  • ENSP00000433720
  • ENST00000533904
  • ENSP00000432816

Symbol
  • SP-10
  • SPACA2
  • D11S4365
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
small molecule perturbation
0.59
virus perturbation
0.59
kinase perturbation
0.54
cellular component
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SP9
Tdark
Family:  TF
Novelty:  0.00476397
Score:  0.86
Data Source:  STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
Score:  0.827
Data Source:  STRINGDB
LIPN
Tbio
Family:  Enzyme
Novelty:  0.00135912
Score:  0.789
Data Source:  STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
Score:  0.741
Data Source:  STRINGDB
SP6
Tbio
Family:  TF
Novelty:  0.00201789
Score:  0.737
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.717
Data Source:  STRINGDB
MBD3L2
Tdark
Novelty:  0.2567825
Score:  0.701
Data Source:  STRINGDB
SP8
Tbio
Family:  TF
Novelty:  0.01028497
Score:  0.67
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.641
Data Source:  STRINGDB
SPACA3
Tbio
Family:  Enzyme
Novelty:  0.04713334
Score:  0.629
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
46.5
serum alanine aminotransferase measurement
1
1
0
5.7
15.1
mean platelet volume
1
1
1
9.9
mean corpuscular hemoglobin concentration
1
1
1
8.3
platelet count
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
46.5
serum alanine aminotransferase measurement
0
5.7
15.1
mean platelet volume
1
9.9
mean corpuscular hemoglobin concentration
1
8.3
platelet count
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acrosomal vesicle protein 1
VGNC:3232
739927
Macaque
acrosomal vesicle protein 1
713422
Mouse
MGI:104590
11451
Rat
RGD:620153
60353
Dog
acrosomal vesicle protein 1
VGNC:37528
607249
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acrosomal vesicle protein 1
Macaque
acrosomal vesicle protein 1
Mouse
Rat
Dog
acrosomal vesicle protein 1
Publication Statistics
PubMed Score 437.10
PubMed score by year
PubTator Score 116.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title