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Tbio
ACP5
Tartrate-resistant acid phosphatase type 5

Protein Summary
Description
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218758
  • ENSP00000218758
  • ENSG00000102575
  • ENST00000412435
  • ENSP00000392374
  • ENST00000433365
  • ENSP00000413456
  • ENST00000592828
  • ENSP00000468767
  • ENST00000648477
  • ENSP00000496973

Symbol
  • HPAP
  • TRAP
  • TRACP5a
  • TRACP5b
  • TrATPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.8
transcription factor
0.76
biological process
0.72
biological term
0.63
chemical
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2607.32   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2607.32   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
p_int:  0.996037303
p_ni:  0.003961562
p_wrong:  0.000001136
Score:  0.54
Data Source:  BioPlex,STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
p_int:  0.993360611
p_ni:  0.006639389
Score:  0.325
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.811029879
p_ni:  0.188970121
Score:  0.205
Data Source:  BioPlex,STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.929
Data Source:  STRINGDB
CTSK
Tchem
Family:  Enzyme
Novelty:  0.0007707
Score:  0.928
Data Source:  STRINGDB
TNFSF11
Tclin
Novelty:  0.00018328
Score:  0.922
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.912
Data Source:  STRINGDB
BLVRB
Tbio
Family:  Enzyme
Novelty:  0.00705559
Score:  0.904
Data Source:  STRINGDB
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
Score:  0.903
Data Source:  STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
Score:  0.887
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (354)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
75.5
antiphospholipid antibody measurement
1
1
0
2.2
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
75.5
antiphospholipid antibody measurement
0
2.2
37.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 5, tartrate resistant
VGNC:14738
104003264
Macaque
acid phosphatase 5, tartrate resistant
715071
Mouse
MGI:87883
11433
Dog
acid phosphatase 5, tartrate resistant
VGNC:37525
476705
Horse
acid phosphatase 5, tartrate resistant
VGNC:14997
100056621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 5, tartrate resistant
Macaque
acid phosphatase 5, tartrate resistant
Mouse
Dog
acid phosphatase 5, tartrate resistant
Horse
acid phosphatase 5, tartrate resistant
Publication Statistics
PubMed Score 2607.32
PubMed score by year
PubTator Score 223.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title