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Tbio
ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

Protein Summary
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336430
  • ENSP00000336580
  • ENSG00000123130
  • ENST00000379295
  • ENSP00000368597
  • ENST00000379303
  • ENSP00000368605

Symbol
  • ACATE2
  • CGI-16
  • MTACT48
  • MT-ACT48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.91
virus perturbation
0.88
interacting protein
0.85
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
GFPT2
Tbio
Family:  Enzyme
Novelty:  0.01049877
p_int:  0.999878799
p_ni:  0.000121201
Score:  0.207
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999573259
p_ni:  0.000426741
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999383687
p_ni:  0.000616313
Data Source:  BioPlex
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.999161218
p_ni:  0.000838782
Data Source:  BioPlex
C6
Tbio
Novelty:  0.0132784
p_int:  0.998416862
p_ni:  0.001583138
Score:  0.25
Data Source:  BioPlex,STRINGDB
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.997985537
p_ni:  0.002014463
Data Source:  BioPlex
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.99659865
p_ni:  0.00340135
Data Source:  BioPlex
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
p_int:  0.986372294
p_ni:  0.013627706
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.982396271
p_ni:  0.017603729
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.950117745
p_ni:  0.049882251
p_wrong:  4e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 9
VGNC:1490
465537
Macaque
acyl-CoA thioesterase 9
697759
Mouse
MGI:1928940
64833
Rat
RGD:1359188
302640
Dog
acyl-CoA thioesterase 9
VGNC:37520
100856631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 9
Macaque
acyl-CoA thioesterase 9
Mouse
Rat
Dog
acyl-CoA thioesterase 9
Publication Statistics
PubMed Score 5.52
PubMed score by year
PubTator Score 4.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title