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Tbio
ACO2
Aconitate hydratase, mitochondrial

Protein Summary
Description
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216254
  • ENSP00000216254
  • ENSG00000100412

Symbol
  • ICRD
  • OCA8
  • OPA9
  • ACONM
  • HEL-S-284
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
protein domain
0.97
interacting protein
0.9
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 423.05   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 423.05   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0