Tbio ACO1 Cytoplasmic aconitate hydratase

Protein Summary

Description

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P21399
• D3DRK7
• Q14652
• Q5VZA7
• Aconitase

Gene Name

• ACO1

Ensembl ID

• ENST00000309951
• ENSP00000309477
• ENSG00000122729
• ENST00000379923
• ENSP00000369255
• ENST00000541043
• ENSP00000438733

Symbol

• IREB1
• IRP1
• ACONS
• HEL60
• IREB1
• IREBP
• IREBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.99
disease perturbation	0.93
transcription factor perturbation	0.91
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Lyase / Hydratase / Cytoplasmic Aconitate Hydratase

Protein / Lyase / Dehydratase / Cytoplasmic Aconitate Hydratase

DTO Classes

Protein / Enzyme / Lyase / Dehydratase / Cytoplasmic Aconitate Hydratase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.71   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 528   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.71   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0