Protein Summary
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
- ENST00000352035
- ENSP00000253792
- ENSG00000131473
- ENST00000353196
- ENSP00000345398
- ENST00000393896
- ENSP00000377474
- ENST00000537919
- ENSP00000445349
- ENST00000590151
- ENSP00000466259
- ACL
- ATPCL
- CLATP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
protein domain | 1 | ||
drug perturbation | 0.99 | ||
molecular function | 0.98 | ||
disease perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 880.25 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 481 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 880.25 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 481 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (19)
Protein-Protein Interactions (305)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (38)
Reactome (9)
KEGG (2)
PathwayCommons (5)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acyl-CoA biosynthesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ChREBP activates metabolic gene expression | ||||
Fatty acid metabolism | ||||
Fatty acyl-CoA biosynthesis | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (4)
Components (9)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 7 | 5 | 7 | 96.5 | |||||
reticulocyte measurement | 3 | 3 | 4 | 94.7 | |||||
balding measurement | 1 | 1 | 1 | 64.4 | |||||
eosinophil count | 2 | 1 | 2 | 48.5 | |||||
heel bone mineral density | 1 | 1 | 1 | 38.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 7 | 96.5 | |||||
reticulocyte measurement | 4 | 94.7 | |||||
balding measurement | 1 | 64.4 | |||||
eosinophil count | 2 | 48.5 | |||||
heel bone mineral density | 1 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATP citrate lyase | VGNC:6326 | 454672 | |||||
Macaque | ATP citrate lyase | 708501 | ||||||
Mouse | MGI:103251 | 104112 | ||||||
Rat | RGD:2018 | 24159 | ||||||
Dog | ATP citrate lyase | VGNC:37511 | 607852 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATP citrate lyase | |||||
Macaque | ATP citrate lyase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP citrate lyase | |||||
Publication Statistics
PubMed Score 880.25
PubMed score by year
PubTator Score 226.51
PubTator score by year
Related Publications
Text Mined References (69)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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