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Tchem
ACKR3
Atypical chemokine receptor 3

Protein Summary
Description
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272928
  • ENSP00000272928
  • ENSG00000144476

Symbol
  • CMKOR1
  • CXCR7
  • GPR159
  • RDC1
  • RDC1
  • CXCR7
  • RDC-1
  • CMKOR1
  • CXC-R7
  • CXCR-7
  • GPR159
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.98
transcription factor perturbation
0.94
small molecule perturbation
0.93
biological term
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.36   (req: < 5)
Gene RIFs: 181   (req: <= 3)
Antibodies: 754   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.36   (req: >= 5)
Gene RIFs: 181   (req: > 3)
Antibodies: 754   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 491
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1