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Tclin
ACHE
Acetylcholinesterase

Protein Summary
Description
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-cont ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241069
  • ENSP00000241069
  • ENSG00000087085
  • ENST00000302913
  • ENSP00000303211
  • ENST00000411582
  • ENSP00000404865
  • ENST00000412389
  • ENSP00000394976
  • ENST00000419336
  • ENSP00000403474
  • ENST00000428317
  • ENSP00000414858

Symbol
  • YT
  • ACEE
  • ARACHE
  • N-ACHE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
biological process
0.91
molecular function
0.91
protein domain
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3171.23   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3171.23   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2500
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 29