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Tchem
ACE2
Angiotensin-converting enzyme 2

Protein Summary
Description
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (By similarity). (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV. (Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252519
  • ENSP00000252519
  • ENSG00000130234
  • ENST00000427411
  • ENSP00000389326

Symbol
  • ACEH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.97
molecular function
0.86
biological process
0.78
disease
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16515.46   (req: < 5)
Gene RIFs: 224   (req: <= 3)
Antibodies: 867   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16515.46   (req: >= 5)
Gene RIFs: 224   (req: > 3)
Antibodies: 867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0