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Tbio
ACAN
Aggrecan core protein

Protein Summary
Description
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352105
  • ENSP00000341615
  • ENSG00000157766
  • ENST00000439576
  • ENSP00000387356
  • ENST00000559004
  • ENSP00000453499
  • ENST00000561243
  • ENSP00000453342

Symbol
  • AGC1
  • CSPG1
  • MSK16
  • AGC1
  • SEDK
  • AGCAN
  • CSPG1
  • MSK16
  • CSPGCP
  • SSOAOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.8
phenotype
0.71
pathway
0.66
cellular component
0.65
disease
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3294.19   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3294.19   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0