You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACADVL
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons. The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350303
  • ENSP00000344152
  • ENSG00000072778
  • ENST00000356839
  • ENSP00000349297
  • ENST00000543245
  • ENSP00000438689

Symbol
  • VLCAD
  • ACAD6
  • LCACD
  • VLCAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.93
cellular component
0.86
biological process
0.84
interacting protein
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.53   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.53   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.999991208
p_ni:  0.000008792
Score:  0.177
Data Source:  BioPlex,STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.999982784
p_ni:  0.000017216
Score:  0.283
Data Source:  BioPlex,STRINGDB
APC
Tchem
Novelty:  0.00168376
p_int:  0.99983188
p_ni:  0.00016812
Score:  0.183
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.994686429
p_ni:  0.005313571
Data Source:  BioPlex
HIBCH
Tbio
Family:  Enzyme
Novelty:  0.02964018
p_int:  0.991082513
p_ni:  0.008917487
Score:  0.845
Data Source:  BioPlex,STRINGDB
SURF1
Tbio
Novelty:  0.00717605
p_int:  0.989601457
p_ni:  0.010398543
Score:  0.313
Data Source:  BioPlex,STRINGDB
SGSM1
Tbio
Novelty:  0.27948733
p_int:  0.988762366
p_ni:  0.011237634
Data Source:  BioPlex
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.987336266
p_ni:  0.012663734
Data Source:  BioPlex
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.913142786
p_ni:  0.086857214
Score:  0.166
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.912256423
p_ni:  0.087743577
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (R-HSA-77305)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Reactome
Fatty acid metabolism
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Fatty acid metabolism
IRE1alpha activates chaperones
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
15.8
99.5
apolipoprotein B measurement
2
6
7
97.8
low density lipoprotein cholesterol measurement
7
5
12
97.1
total cholesterol measurement
4
4
8
95.8
birth weight
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
15.8
99.5
apolipoprotein B measurement
7
97.8
low density lipoprotein cholesterol measurement
12
97.1
total cholesterol measurement
8
95.8
birth weight
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase very long chain
VGNC:12022
455237
Macaque
acyl-CoA dehydrogenase very long chain
714326
Mouse
MGI:895149
11370
Rat
RGD:2014
25363
Dog
acyl-CoA dehydrogenase very long chain
VGNC:53258
489463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase very long chain
Macaque
acyl-CoA dehydrogenase very long chain
Mouse
Rat
Dog
acyl-CoA dehydrogenase very long chain
Publication Statistics
PubMed Score 277.53
PubMed score by year
PubTator Score 146.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title