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Tbio
ACADSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent. Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358776
  • ENSP00000357873
  • ENSG00000196177
  • ENST00000368869
  • ENSP00000357862

Symbol
  • ACAD7
  • SBCAD
  • 2-MEBCAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.83
small molecule perturbation
0.78
protein domain
0.73
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.997218531
p_ni:  0.002781469
Data Source:  BioPlex
PCSK1
Tchem
Family:  Enzyme
Novelty:  0.00315256
p_int:  0.979309494
p_ni:  0.020690506
Data Source:  BioPlex
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.757524861
p_ni:  0.242475112
p_wrong:  2.7e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.983
Data Source:  STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.966
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.964
Data Source:  STRINGDB
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
Score:  0.959
Data Source:  STRINGDB
HADHB
Tbio
Family:  Enzyme
Novelty:  0.00969194
Score:  0.956
Data Source:  STRINGDB
EHHADH
Tbio
Novelty:  0.00878193
Score:  0.955
Data Source:  STRINGDB
ACAT2
Tchem
Family:  Enzyme
Novelty:  0.01464168
Score:  0.95
Data Source:  STRINGDB
Pathways (33)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.5
low density lipoprotein cholesterol measurement
4
3
4
89.5
apolipoprotein B measurement
1
1
1
56.8
mean reticulocyte volume
1
1
1
56
reticulocyte measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.5
low density lipoprotein cholesterol measurement
4
89.5
apolipoprotein B measurement
1
56.8
mean reticulocyte volume
1
56
reticulocyte measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase short/branched chain
VGNC:51961
745464
Macaque
acyl-CoA dehydrogenase short/branched chain
707487
Mouse
MGI:1914135
66885
Rat
RGD:2013
25618
Dog
acyl-CoA dehydrogenase short/branched chain
VGNC:52979
477856
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase short/branched chain
Macaque
acyl-CoA dehydrogenase short/branched chain
Mouse
Rat
Dog
acyl-CoA dehydrogenase short/branched chain
Publication Statistics
PubMed Score 37.63
PubMed score by year
PubTator Score 17.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title