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Tbio
ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms. This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242592
  • ENSP00000242592
  • ENSG00000122971

Symbol
  • SCAD
  • ACAD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
small molecule perturbation
0.75
protein domain
0.73
kinase perturbation
0.71
molecular function
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.58   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.58   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.998813817
p_ni:  0.001183017
p_wrong:  0.000003166
Score:  0.152
Data Source:  BioPlex,STRINGDB
SEC22C
Tdark
Novelty:  0.53697928
p_int:  0.993387637
p_ni:  0.006612363
Score:  0.455
Data Source:  BioPlex,STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
p_int:  0.963736391
p_ni:  0.036263604
p_wrong:  5e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
LYRM2
Tdark
Novelty:  0.33936166
p_int:  0.949449933
p_ni:  0.050550067
Score:  0.19
Data Source:  BioPlex,STRINGDB
STX5
Tbio
Novelty:  0.00964918
p_int:  0.924478598
p_ni:  0.075521402
Score:  0.166
Data Source:  BioPlex,STRINGDB
KIF6
Tbio
Novelty:  0.02486302
p_int:  0.901470495
p_ni:  0.098529505
Score:  0.209
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
p_int:  0.809639835
p_ni:  0.190360165
Score:  0.224
Data Source:  BioPlex,STRINGDB
SUN2
Tbio
Novelty:  0.01387591
p_int:  0.755023506
p_ni:  0.244976494
Score:  0.214
Data Source:  BioPlex,STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.99
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (21)
Beta oxidation of butanoyl-CoA to acetyl-CoA (R-HSA-77352)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of butanoyl-CoA to acetyl-CoA
Reactome
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta oxidation of butanoyl-CoA to acetyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
5
5
99.1
serum metabolite measurement
3
4
5
98.2
C-reactive protein measurement
2
13
13
97.9
serum gamma-glutamyl transferase measurement
1
10
10
97.1
red blood cell distribution width
4
3
4
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
5
99.1
serum metabolite measurement
5
98.2
C-reactive protein measurement
13
97.9
serum gamma-glutamyl transferase measurement
10
97.1
red blood cell distribution width
4
95.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase short chain
VGNC:12753
742921
Macaque
acyl-CoA dehydrogenase short chain
698196
Mouse
MGI:87868
11409
Rat
RGD:620514
64304
Dog
acyl-CoA dehydrogenase short chain
VGNC:52915
477517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase short chain
Macaque
acyl-CoA dehydrogenase short chain
Mouse
Rat
Dog
acyl-CoA dehydrogenase short chain
Publication Statistics
PubMed Score 129.58
PubMed score by year
PubTator Score 96.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title