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Tbio
ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233710
  • ENSP00000233710
  • ENSG00000115361

Symbol
  • LCAD
  • ACAD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
disease perturbation
0.79
molecular function
0.76
histone modification site profile
0.75
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.43   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.43   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
TMPRSS11A
Tbio
Family:  Enzyme
Novelty:  0.06142295
p_int:  0.999955418
p_ni:  0.000044582
Score:  0.534
Data Source:  BioPlex,STRINGDB
GMFB
Tbio
Novelty:  0.01531815
p_int:  0.999544513
p_ni:  0.000454503
p_wrong:  9.84e-7
Data Source:  BioPlex
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999319157
p_ni:  0.000680625
p_wrong:  2.18e-7
Data Source:  BioPlex
APP
Tclin
Novelty:  0.00008964
p_int:  0.997756917
p_ni:  0.002243083
Score:  0.192
Data Source:  BioPlex,STRINGDB
SYT2
Tbio
Novelty:  0.00754735
p_int:  0.994181201
p_ni:  0.001880611
p_wrong:  0.003938188
Score:  0.54
Data Source:  BioPlex,STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
p_int:  0.990547684
p_ni:  0.009452316
Score:  0.357
Data Source:  BioPlex,STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
Score:  0.972
Data Source:  STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.969
Data Source:  STRINGDB
ACSL1
Tchem
Family:  Enzyme
Novelty:  0.00336161
Score:  0.968
Data Source:  STRINGDB
HADHB
Tbio
Family:  Enzyme
Novelty:  0.00969194
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (R-HSA-77310)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Reactome
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
3
97.9
serum metabolite measurement
2
3
3
96.5
urinary metabolite measurement
2
2
2
96.4
metabolite measurement
1
1
1
95.4
acylcarnitine measurement
1
1
1
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
97.9
serum metabolite measurement
3
96.5
urinary metabolite measurement
2
96.4
metabolite measurement
1
95.4
acylcarnitine measurement
1
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase long chain
VGNC:14310
459914
Macaque
acyl-CoA dehydrogenase long chain
711485
Mouse
MGI:87866
11363
Rat
RGD:2011
25287
Dog
acyl-CoA dehydrogenase long chain
VGNC:37493
478895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase long chain
Macaque
acyl-CoA dehydrogenase long chain
Mouse
Rat
Dog
acyl-CoA dehydrogenase long chain
Publication Statistics
PubMed Score 36.43
PubMed score by year
PubTator Score 32.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title