Tbio ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial

Protein Summary

Description

Required for mitochondrial complex I assembly (PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9H845
• D3DNB8
• Q8WXX3
• ACAD-9

Gene Name

• ACAD9

Ensembl ID

• ENST00000308982
• ENSP00000312618
• ENSG00000177646

Symbol

• NPD002
• MC1DN20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
disease perturbation	0.79
kinase perturbation	0.76
protein domain	0.73
interacting protein	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Acyl-coa Dehydrogenase Family Member 9, Mitochondrial

Protein / Oxidoreductase / Oxidase / Acyl-coa Dehydrogenase Family Member 9, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Acyl-coa Dehydrogenase Family Member 9, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Acyl-coa Dehydrogenase Family Member 9, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0