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Tchem
ACAD10
Acyl-CoA dehydrogenase family member 10

Protein Summary
Description
Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313698
  • ENSP00000325137
  • ENSG00000111271
  • ENST00000455480
  • ENSP00000389813
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.94
molecular function
0.67
transcription factor
0.67
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.999558883
p_ni:  0.000441117
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.999502142
p_ni:  0.000497858
Data Source:  BioPlex
NDUFA10
Tclin
Family:  Enzyme
Novelty:  0.06260343
p_int:  0.999416779
p_ni:  0.000583221
Score:  0.201
Data Source:  BioPlex,STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.980724127
p_ni:  0.019273662
p_wrong:  0.000002211
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.979743632
p_ni:  0.020256368
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.975806907
p_ni:  0.02418948
p_wrong:  0.000003612
Data Source:  BioPlex
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.962233384
p_ni:  0.037766616
Score:  0.244
Data Source:  BioPlex,STRINGDB
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.954144562
p_ni:  0.045855265
p_wrong:  1.73e-7
Data Source:  BioPlex
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.944605465
p_ni:  0.055394535
Score:  0.431
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.941273193
p_ni:  0.058726807
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (68)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
4
4
97.9
mean corpuscular hemoglobin concentration
3
3
3
97.5
4
3
0
1.8
96.1
platelet count
4
4
3
3.7
94.2
fish consumption measurement
2
2
2
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
97.9
mean corpuscular hemoglobin concentration
3
97.5
0
1.8
96.1
platelet count
3
3.7
94.2
fish consumption measurement
2
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 10
VGNC:52034
452250
Macaque
acyl-CoA dehydrogenase family member 10
711080
Mouse
MGI:1919235
71985
Rat
RGD:1310159
304500
Dog
acyl-CoA dehydrogenase family member 10 [Source:HGNC Symbol;Acc:HGNC:21597]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 10
Macaque
acyl-CoA dehydrogenase family member 10
Mouse
Rat
Dog
acyl-CoA dehydrogenase family member 10 [Source:HGNC Symbol;Acc:HGNC:21597]
Publication Statistics
PubMed Score 11.50
PubMed score by year
PubTator Score 7.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title