Tchem ACACA Acetyl-CoA carboxylase 1

Protein Summary

Description

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13085
• B2RP68
• Q6KEV6
• Q6XDA8
• Q7Z2G8
• Q7Z561
• Q7Z563
• Q7Z564
• Q86WB2
• Q86WB3
• ACC1

Gene Name

• ACACA

Ensembl ID

• ENST00000611803
• ENSP00000479901
• ENSG00000275176
• ENST00000612895
• ENSP00000482269
• ENSG00000278540
• ENST00000613687
• ENSP00000483674
• ENST00000614428
• ENSP00000478547
• ENST00000616317
• ENSP00000483300
• ENST00000617649
• ENSP00000482368
• ENST00000619487
• ENSP00000478577
• ENST00000621312
• ENSP00000480031

Symbol

• ACAC
• ACC1
• ACCA
• ACC
• ACAC
• ACC1
• ACCA
• ACACAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein domain	1
biological process	0.97
molecular function	0.94
transcription factor	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.47   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 581   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.47   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 287

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (287)

Explore Active Ligands

1 – 10 of 287

CHEMBL1818291

ACACATchem Enzyme

pIC50 : 7.28

CHEMBL2419596

ACACATchem Enzyme

pIC50 : 8.4

TOFA

ACACATchem Enzyme

pIC50 : 4.91

CHEMBL4060253

ACACATchem Enzyme

pIC50 : 9.12

CHEMBL4085633

ACACATchem Enzyme

pIC50 : 9.02

CHEMBL4086127

ACACATchem Enzyme

pIC50 : 9.02

CHEMBL4528475

ACACATchem Enzyme

pIC50 : 8.82

Firsocostat

ACACATchem Enzyme

pIC50 : 8.77

CHEMBL2419600

ACACATchem Enzyme

pIC50 : 8.96

CHEMBL4435891

ACACATchem Enzyme

pIC50 : 8.68

Protein-Protein Interactions (201)

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1 – 10 of 201

• See Interactions on String-DB

MID1IP1

Tbio

Novelty:  0.11443752

p_int:  0.999904045

p_ni:  0.000095955

Score:  0.492

Data Source:  BioPlex,STRINGDB

OAS2

Tbio

Family:  Enzyme

Novelty:  0.01673393

p_int:  0.999807845

p_ni:  0.000192155

Score:  0.269

Data Source:  BioPlex,STRINGDB

THRSP

Tbio

Novelty:  0.00938864

p_int:  0.999231516

p_ni:  0.000768484

Score:  0.656

Data Source:  BioPlex,STRINGDB

LGALS3BP

Tbio

Novelty:  0.0025302

p_int:  0.992027139

p_ni:  0.007972861

Data Source:  BioPlex

ODAPH

Tbio

Novelty:  0.20386223

p_int:  0.989582378

p_ni:  0.010417622

Data Source:  BioPlex

EGLN3

Tclin

Novelty:  0.00643992

p_int:  0.984992108

p_ni:  0.015007892

Data Source:  BioPlex

PSG1

Tbio

Novelty:  0.0239046

p_int:  0.974052539

p_ni:  0.025947461

Score:  0.181

Data Source:  BioPlex,STRINGDB

SGCZ

Tbio

Novelty:  0.08511312

p_int:  0.928173054

p_ni:  0.071826946

Score:  0.187

Data Source:  BioPlex,STRINGDB

TNS4

Tbio

Novelty:  0.048713

p_int:  0.861707664

p_ni:  0.138292336

Data Source:  BioPlex

FNDC11

Tdark

Novelty:  20.00979352

p_int:  0.817664629

p_ni:  0.182335371

Score:  0.309

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

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Upstream (2)

1 – 2 of 2

ABAT

Tclin

Family:  Enzyme

KEGG Distance:  2

Common Pathways:  2

1: Propanoate metabolism

2: Metabolic pathways

ADRA1A

Tclin

Family:  GPCR

KEGG Distance:  2

Common Pathways:  1

1: AMPK signaling pathway

Pathways (78)

Reactome (17)

KEGG (8)

PathwayCommons (2)

UniProt (1)

WikiPathways (50)

Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Reactome	Biotin transport and metabolism	11 targets	R-HSA-196780
Reactome	ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Reactome	Defective HLCS causes multiple carboxylase deficiency	7 targets	R-HSA-3371599
Reactome	Defects in biotin (Btn) metabolism	8 targets	R-HSA-3323169

Name	Explore in Pharos	Explore in Source
Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Biotin transport and metabolism	11 targets	R-HSA-196780
ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Defective HLCS causes multiple carboxylase deficiency	7 targets	R-HSA-3371599
Defects in biotin (Btn) metabolism	8 targets	R-HSA-3323169

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (5)

Components (3)

Processes (12)

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1 – 5 of 5

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
acetyl-CoA carboxylase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
biotin carboxylase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (26)

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5

1 – 5 of 26

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	ENSG00000275176	2	1	2		82.4
monocyte count	EFO_0005091	ENSG00000278540	2	1	2		82.4
platelet crit	EFO_0007985	ENSG00000275176	2	2	2		75.9
platelet crit	EFO_0007985	ENSG00000278540	2	2	2		75.9
daytime rest measurement	EFO_0007828	ENSG00000275176	1	1	1		74.4

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5

1 – 5 of 26

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	2		82.4
monocyte count	EFO_0005091	2		82.4
platelet crit	EFO_0007985	2		75.9
platelet crit	EFO_0007985	2		75.9
daytime rest measurement	EFO_0007828	1		74.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Allosteric enzyme
Alternative promoter usage
ATP-binding
Biotin
Complete proteome
Cytoplasm
Direct protein sequencing
Fatty acid biosynthesis

GWAS Trait Find Similar Targets

No Header	No Header
daytime rest measurement
hematocrit
hemoglobin measurement
hip bone size
leukocyte count
lymphocyte count
macrophage inflammatory protein 1b measurement
monocyte count
monocyte percentage of leukocytes
myeloid white cell count

MGI Phenotype Find Similar Targets

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embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	acetyl-CoA carboxylase alpha		714218
Mouse	acetyl-Coenzyme A carboxylase alpha	MGI:108451	107476
Rat	acetyl-CoA carboxylase alpha	RGD:621248	60581
Dog	acetyl-CoA carboxylase alpha	VGNC:37489	491130
Horse	acetyl-CoA carboxylase alpha	VGNC:14961	100071472

Species	Name	OMA	EggNOG	Inparanoid
Macaque	acetyl-CoA carboxylase alpha
Mouse	acetyl-Coenzyme A carboxylase alpha
Rat	acetyl-CoA carboxylase alpha
Dog	acetyl-CoA carboxylase alpha
Horse	acetyl-CoA carboxylase alpha

Publication Statistics

PubMed Score 390.47

PubMed score by year

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PubTator Score 142.81

PubTator score by year

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Related Publications

Text Mined References (75)

GeneRif Annotations (45)

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PMID	Year	Title