Protein Summary
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000611803
- ENSP00000479901
- ENSG00000275176
- ENST00000612895
- ENSP00000482269
- ENSG00000278540
- ENST00000613687
- ENSP00000483674
- ENST00000614428
- ENSP00000478547
- ENST00000616317
- ENSP00000483300
- ENST00000617649
- ENSP00000482368
- ENST00000619487
- ENSP00000478577
- ENST00000621312
- ENSP00000480031
- ACAC
- ACC1
- ACCA
- ACC
- ACAC
- ACC1
- ACCA
- ACACAD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
protein domain | 1 | ||
biological process | 0.97 | ||
molecular function | 0.94 | ||
transcription factor | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 390.47 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 581 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 390.47 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 581 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 287
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (287)
Protein-Protein Interactions (201)
MID1IP1
Novelty: 0.11443752
p_int: 0.999904045
p_ni: 0.000095955
Score: 0.492
Data Source: BioPlex,STRINGDB
OAS2
Family: Enzyme
Novelty: 0.01673393
p_int: 0.999807845
p_ni: 0.000192155
Score: 0.269
Data Source: BioPlex,STRINGDB
THRSP
Novelty: 0.00938864
p_int: 0.999231516
p_ni: 0.000768484
Score: 0.656
Data Source: BioPlex,STRINGDB
PSG1
Novelty: 0.0239046
p_int: 0.974052539
p_ni: 0.025947461
Score: 0.181
Data Source: BioPlex,STRINGDB
SGCZ
Novelty: 0.08511312
p_int: 0.928173054
p_ni: 0.071826946
Score: 0.187
Data Source: BioPlex,STRINGDB
FNDC11
Novelty: 20.00979352
p_int: 0.817664629
p_ni: 0.182335371
Score: 0.309
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (78)
Reactome (17)
KEGG (8)
PathwayCommons (2)
UniProt (1)
WikiPathways (50)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Biotin transport and metabolism | ||||
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Defective HLCS causes multiple carboxylase deficiency | ||||
Reactome | Defects in biotin (Btn) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Biotin transport and metabolism | ||||
ChREBP activates metabolic gene expression | ||||
Defective HLCS causes multiple carboxylase deficiency | ||||
Defects in biotin (Btn) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (5)
Components (3)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
monocyte count | 2 | 1 | 2 | 82.4 | ||||||
monocyte count | 2 | 1 | 2 | 82.4 | ||||||
platelet crit | 2 | 2 | 2 | 75.9 | ||||||
platelet crit | 2 | 2 | 2 | 75.9 | ||||||
daytime rest measurement | 1 | 1 | 1 | 74.4 | ||||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte count | 2 | 82.4 | |||||
monocyte count | 2 | 82.4 | |||||
platelet crit | 2 | 75.9 | |||||
platelet crit | 2 | 75.9 | |||||
daytime rest measurement | 1 | 74.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | acetyl-CoA carboxylase alpha | 714218 | ||||||
Mouse | MGI:108451 | 107476 | ||||||
Rat | RGD:621248 | 60581 | ||||||
Dog | acetyl-CoA carboxylase alpha | VGNC:37489 | 491130 | |||||
Horse | acetyl-CoA carboxylase alpha | VGNC:14961 | 100071472 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | acetyl-CoA carboxylase alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | acetyl-CoA carboxylase alpha | |||||
Horse | acetyl-CoA carboxylase alpha | |||||
Publication Statistics
PubMed Score 390.47
PubMed score by year
PubTator Score 142.81
PubTator score by year
Related Publications
Text Mined References (75)
GeneRif Annotations (45)
Items per page:
0 of 0
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