Tbio ACAA1 3-ketoacyl-CoA thiolase, peroxisomal

Protein Summary

Description

This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09110
• G5E935
• Q96CA6

Gene Name

• ACAA1

Ensembl ID

• ENST00000301810
• ENSP00000301810
• ENSG00000060971
• ENST00000333167
• ENSP00000333664

Symbol

• ACAA
• PTHIO
• ACAA
• THIO
• PTHIO

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
protein domain	0.97
transcription factor perturbation	0.91
virus perturbation	0.9
transcription factor	0.77

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / 3-ketoacyl-coa Thiolase, Peroxisomal

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / 3-ketoacyl-coa Thiolase, Peroxisomal

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.92   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.92   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0