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Tbio
ACAA1
3-ketoacyl-CoA thiolase, peroxisomal

Protein Summary
Description
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301810
  • ENSP00000301810
  • ENSG00000060971
  • ENST00000333167
  • ENSP00000333664

Symbol
  • ACAA
  • PTHIO
  • ACAA
  • THIO
  • PTHIO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
0.97
transcription factor perturbation
0.91
virus perturbation
0.9
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
C6orf226
Tdark
Novelty:  4.2303719
p_int:  0.999999999
p_ni:  1e-9
Score:  0.859
Data Source:  BioPlex,STRINGDB
PEX7
Tbio
Novelty:  0.01487923
p_int:  0.999985173
p_ni:  0.000009345
p_wrong:  0.000005482
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.995815492
p_ni:  0.00418437
p_wrong:  1.38e-7
Data Source:  BioPlex
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
p_int:  0.968875283
p_ni:  0.031123949
p_wrong:  7.68e-7
Data Source:  BioPlex
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.96183203
p_ni:  0.03816797
Score:  0.232
Data Source:  BioPlex,STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
p_int:  0.892850993
p_ni:  0.107149007
Score:  0.505
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.881128382
p_ni:  0.118847855
p_wrong:  0.000023763
Data Source:  BioPlex
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.836854887
p_ni:  0.163102232
p_wrong:  0.000042881
Score:  0.183
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.804833421
p_ni:  0.195161996
p_wrong:  0.000004583
Data Source:  BioPlex
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.998
Data Source:  STRINGDB
Pathways (36)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Immune System
Innate Immune System
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
75.6
mean corpuscular volume
1
1
1
72.6
HbA1c measurement
1
1
1
50.6
reticulocyte measurement
1
1
1
31.4
mean corpuscular hemoglobin concentration
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
75.6
mean corpuscular volume
1
72.6
HbA1c measurement
1
50.6
reticulocyte measurement
1
31.4
mean corpuscular hemoglobin concentration
1
3.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acyltransferase 1
VGNC:1987
460268
Macaque
acetyl-CoA acyltransferase 1
696743
Mouse
MGI:3605455
235674
Rat
RGD:67379
24157
Dog
acetyl-CoA acyltransferase 1
VGNC:37488
477023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acyltransferase 1
Macaque
acetyl-CoA acyltransferase 1
Mouse
Rat
Dog
acetyl-CoA acyltransferase 1
Publication Statistics
PubMed Score 125.73
PubMed score by year
PubTator Score 78.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title