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Tbio
ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

Protein Summary
Description
May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes. This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232744
  • ENSP00000232744
  • ENSG00000114626
  • ENST00000453791
  • ENSP00000412684
  • ENST00000468137
  • ENSP00000417366

Symbol
  • BPOZ
  • BPOZ
  • BTB3
  • BTBD21
  • EF1ABP
  • PP2259
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
protein domain
0.73
transcription factor
0.67
tissue sample
0.59
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.999996358
p_ni:  0.000003641
Score:  0.307
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.999837981
p_ni:  0.000162019
Score:  0.751
Data Source:  BioPlex,STRINGDB
CARS
Tchem
Family:  Enzyme
Novelty:  0.02078279
p_int:  0.998282948
p_ni:  0.001717052
Score:  0.859
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.996621947
p_ni:  0.003378053
Score:  0.831
Data Source:  BioPlex,STRINGDB
VARS
Tchem
Family:  Enzyme
Novelty:  0.00720227
p_int:  0.990772045
p_ni:  0.009227954
Score:  0.867
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.913
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.865
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.763
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.755
Data Source:  STRINGDB
FBXO9
Tbio
Novelty:  0.2145394
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
52
high density lipoprotein cholesterol measurement
1
1
1
49.5
triglyceride measurement
1
1
1
36.5
refractive error measurement
1
1
1
26.1
BMI-adjusted waist-hip ratio
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
52
high density lipoprotein cholesterol measurement
1
49.5
triglyceride measurement
1
36.5
refractive error measurement
1
26.1
BMI-adjusted waist-hip ratio
1
6.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and BTB domain containing 1
VGNC:7955
471067
Macaque
ankyrin repeat and BTB domain containing 1
710603
Mouse
MGI:1933148
80283
Rat
RGD:1359363
297432
Dog
ankyrin repeat and BTB domain containing 1
VGNC:37486
609299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and BTB domain containing 1
Macaque
ankyrin repeat and BTB domain containing 1
Mouse
Rat
Dog
ankyrin repeat and BTB domain containing 1
Publication Statistics
PubMed Score 13.50
PubMed score by year
PubTator Score 5.62
PubTator score by year
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Related Publications
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PMID
Year
Title