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Tbio
ABRAXAS2
BRISC complex subunit Abraxas 2

Protein Summary
Description
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298492
  • ENSP00000298492
  • ENSG00000165660

Symbol
  • ABRO1
  • FAM175B
  • KIAA0157
  • ABRO1
  • FAM175B
  • KIAA0157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
BABAM1
Tbio
Novelty:  0.03812501
p_int:  0.999993372
p_ni:  0.000006628
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.999990887
p_ni:  0.000009113
Score:  0.53
Data Source:  BioPlex,STRINGDB
C9orf85
Tdark
Novelty:  4.61061386
p_int:  0.999977399
p_ni:  0.000022601
Data Source:  BioPlex
DNAJC25
Tdark
Novelty:  1.55044803
p_int:  0.999882177
p_ni:  0.000117821
p_wrong:  2e-9
Data Source:  BioPlex
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
p_int:  0.999874042
p_ni:  0.000125958
Score:  0.976
Data Source:  BioPlex,STRINGDB
C2orf73
Tdark
Novelty:  0.8689571
p_int:  0.99983852
p_ni:  0.000161479
Data Source:  BioPlex
BRCC3
Tbio
Family:  Enzyme
Novelty:  0.04661632
p_int:  0.997929517
p_ni:  0.002070483
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
p_int:  0.997209271
p_ni:  0.002790655
p_wrong:  7.4e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.991452349
p_ni:  0.008547651
Data Source:  BioPlex
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.989330431
p_ni:  0.010669568
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
4
3
6.6
89.8
mean platelet volume
2
2
2
75.7
body height
1
2
2
74.5
urate measurement
1
1
1
67.3
mathematical ability
4
1
4
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
6.6
89.8
mean platelet volume
2
75.7
body height
2
74.5
urate measurement
1
67.3
mathematical ability
4
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abraxas 2, BRISC complex subunit
VGNC:3848
100611342
Macaque
abraxas 2, BRISC complex subunit
694886
Mouse
MGI:1926116
109359
Rat
RGD:1308918
293570
Dog
abraxas 2, BRISC complex subunit
VGNC:37484
477859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abraxas 2, BRISC complex subunit
Macaque
abraxas 2, BRISC complex subunit
Mouse
Rat
Dog
abraxas 2, BRISC complex subunit
Publication Statistics
PubMed Score 7.39
PubMed score by year
PubTator Score 3.73
PubTator score by year
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Related Publications
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PMID
Year
Title