ABLIM3
Actin-binding LIM protein 3
Protein Summary
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]
- ENST00000309868
- ENSP00000310309
- ENSG00000173210
- ENST00000326685
- ENSP00000315841
- ENST00000504238
- ENSP00000421183
- ENST00000506113
- ENSP00000425394
- ENST00000517451
- ENSP00000430150
- KIAA0843
- HMFN1661
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.86 | ||
tissue sample | 0.74 | ||
biological process | 0.66 | ||
transcription factor binding site profile | 0.64 | ||
microRNA | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.02 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.02 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (50)
BRCA1
Novelty: 0.00011146
p_int: 0.999887057
p_ni: 0.000079891
p_wrong: 0.000033053
Data Source: BioPlex
CCNH
Novelty: 0.00693072
p_int: 0.998359206
p_ni: 0.001640746
p_wrong: 4.8e-8
Data Source: BioPlex
AFDN
Novelty: 0.00372947
p_int: 0.99672116
p_ni: 0.003278793
p_wrong: 4.7e-8
Data Source: BioPlex
LIMD1
Novelty: 0.04868333
p_int: 0.995464331
p_ni: 0.004500546
p_wrong: 0.000035123
Data Source: BioPlex
PDLIM7
Novelty: 0.00544518
p_int: 0.966068454
p_ni: 0.033931466
p_wrong: 8e-8
Data Source: BioPlex
MNAT1
Family: Enzyme
Novelty: 0.02484936
p_int: 0.916421747
p_ni: 0.083574632
p_wrong: 0.00000362
Data Source: BioPlex
TARBP1
Family: Enzyme
Novelty: 0.04886897
p_int: 0.79861179
p_ni: 0.201382159
p_wrong: 0.000006051
Data Source: BioPlex
UBR1
Family: Enzyme
Novelty: 0.00998888
p_int: 0.770486967
p_ni: 0.229513033
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | DCC mediated attractive signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | Netrin-1 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
DCC mediated attractive signaling | ||||
Developmental Biology | ||||
Netrin-1 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
forced expiratory volume | 2 | 2 | 2 | 74 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 59.5 | |||||
vital capacity | 1 | 1 | 1 | 33.1 | |||||
glomerular filtration rate | 1 | 1 | 1 | 30.2 | |||||
electrocardiography | 1 | 1 | 2 | 21.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
forced expiratory volume | 2 | 74 | |||||
BMI-adjusted waist-hip ratio | 1 | 59.5 | |||||
vital capacity | 1 | 33.1 | |||||
glomerular filtration rate | 1 | 30.2 | |||||
electrocardiography | 2 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | actin binding LIM protein family member 3 | VGNC:3887 | 741703 | |||||
Macaque | actin binding LIM protein family member 3 | 709180 | ||||||
Mouse | MGI:2442582 | 319713 | ||||||
Rat | RGD:1565118 | 307395 | ||||||
Dog | actin binding LIM protein family member 3 | VGNC:37480 | 612309 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | actin binding LIM protein family member 3 | |||||
Macaque | actin binding LIM protein family member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actin binding LIM protein family member 3 | |||||
Publication Statistics
PubMed Score 4.02
PubMed score by year
PubTator Score 2.75
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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