ABLIM3
Actin-binding LIM protein 3
Protein Summary
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]
- ENST00000309868
- ENSP00000310309
- ENSG00000173210
- ENST00000326685
- ENSP00000315841
- ENST00000504238
- ENSP00000421183
- ENST00000506113
- ENSP00000425394
- ENST00000517451
- ENSP00000430150
- KIAA0843
- HMFN1661
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.86 | ||
tissue sample | 0.74 | ||
biological process | 0.66 | ||
transcription factor binding site profile | 0.64 | ||
microRNA | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.48 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.48 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0