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Tclin
ABL1
Tyrosine-protein kinase ABL1

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318560
  • ENSP00000323315
  • ENSG00000097007
  • ENST00000372348
  • ENSP00000361423

Symbol
  • ABL
  • JTK7
  • ABL
  • JTK7
  • p150
  • c-ABL
  • v-abl
  • CHDSKM
  • c-ABL1
  • bcr/abl
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical bioactivity profile
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4772.76   (req: < 5)
Gene RIFs: 482   (req: <= 3)
Antibodies: 2041   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4772.76   (req: >= 5)
Gene RIFs: 482   (req: > 3)
Antibodies: 2041   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 120
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1134
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
bosutinib
Rendered image for bosutinib
dasatinib
Rendered image for dasatinib
nintedanib
Rendered image for nintedanib
ponatinib
Rendered image for ponatinib
imatinib
Rendered image for imatinib
nilotinib
Rendered image for nilotinib
crizotinib
Rendered image for crizotinib
axitinib
Rendered image for axitinib
vandetanib
Rendered image for vandetanib
radotinib
Rendered image for radotinib
Protein-Protein Interactions (459)
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.846653982
p_ni:  6e-9
p_wrong:  0.153346013
Score:  0.998
Data Source:  BioPlex,STRINGDB
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.80855585
p_ni:  5e-9
p_wrong:  0.191444145
Score:  0.984
Data Source:  BioPlex,STRINGDB
ABI1
Tbio
Novelty:  0.00796638
Score:  0.997
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.996
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.99
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.988
Data Source:  Reactome,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.987
Data Source:  STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
Score:  0.982
Data Source:  STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.982
Data Source:  Reactome,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.98
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (82)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin D associated events in G1
Reactome
DNA Double Strand Break Response
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell Cycle
Cell Cycle, Mitotic
Cyclin D associated events in G1
DNA Double Strand Break Response
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (135)
Find Similar Targets
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
82.6
red blood cell distribution width
2
2
2
78.7
lymphocyte count
2
2
2
72.4
myeloid white cell count
1
1
1
65.9
platelet count
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
82.6
red blood cell distribution width
2
78.7
lymphocyte count
2
72.4
myeloid white cell count
1
65.9
platelet count
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ABL proto-oncogene 1, non-receptor tyrosine kinase
VGNC:4596
107976801
Macaque
ABL proto-oncogene 1, non-receptor tyrosine kinase
722449
Mouse
MGI:87859
11350
Rat
RGD:1584969
311860
Dog
ABL proto-oncogene 1, non-receptor tyrosine kinase
491292
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ABL proto-oncogene 1, non-receptor tyrosine kinase
Macaque
ABL proto-oncogene 1, non-receptor tyrosine kinase
Mouse
Rat
Dog
ABL proto-oncogene 1, non-receptor tyrosine kinase
Publication Statistics
PubMed Score 4772.76
PubMed score by year
PubTator Score 5494.32
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title