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Tbio
ABI2
Abl interactor 2

Protein Summary
Description
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Partic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261017
  • ENSP00000261017
  • ENSG00000138443

Symbol
  • ARGBPIA
  • AIP1
  • ABI-2
  • ABI2B
  • AIP-1
  • AblBP3
  • argBP1
  • SSH3BP2
  • argBPIA
  • argBPIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.91
molecular function
0.84
microRNA
0.8
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.25   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.25   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
WASF3
Tbio
Novelty:  0.0248378
p_int:  1
Score:  0.989
Data Source:  BioPlex,STRINGDB
RAPH1
Tbio
Novelty:  0.02440794
p_int:  0.999999998
p_ni:  2e-9
Score:  0.867
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999999989
p_ni:  1e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999999908
p_ni:  9.2e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999999905
p_ni:  9.2e-8
p_wrong:  3e-9
Data Source:  BioPlex
NHSL1
Tdark
Novelty:  0.28557146
p_int:  0.999999901
p_ni:  9.9e-8
Score:  0.754
Data Source:  BioPlex,STRINGDB
CASKIN2
Tdark
Novelty:  0.43801968
p_int:  0.999999889
p_ni:  1e-7
p_wrong:  1.1e-8
Score:  0.72
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999875
p_ni:  1.09e-7
p_wrong:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999999602
p_ni:  3.92e-7
p_wrong:  6e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.999999164
p_ni:  8.36e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
1
1
10.1
79.7
total cholesterol measurement
1
2
2
76.2
apolipoprotein B measurement
2
2
2
73.4
butyrylcholinesterase measurement
1
1
1
69.8
low density lipoprotein cholesterol measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
10.1
79.7
total cholesterol measurement
2
76.2
apolipoprotein B measurement
2
73.4
butyrylcholinesterase measurement
1
69.8
low density lipoprotein cholesterol measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abl interactor 2
VGNC:10523
459892
Macaque
abl interactor 2
704956
Mouse
MGI:106913
329165
Rat
RGD:628771
286928
Dog
abl interactor 2
VGNC:37475
488485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abl interactor 2
Macaque
abl interactor 2
Mouse
Rat
Dog
abl interactor 2
Publication Statistics
PubMed Score 41.25
PubMed score by year
PubTator Score 22.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title