Protein Summary
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin po ...more
- ENST00000346832
- ENSP00000279599
- ENSG00000136754
- ENST00000359188
- ENSP00000352114
- ENST00000376137
- ENSP00000365307
- ENST00000376138
- ENSP00000365308
- ENST00000376139
- ENSP00000365309
- ENST00000376140
- ENSP00000365310
- ENST00000376142
- ENSP00000365312
- ENST00000376166
- ENSP00000365336
- ENST00000376170
- ENSP00000365340
- ENST00000490841
- ENSP00000440101
- SSH3BP1
- E3B1
- ABI-1
- ABLBP4
- NAP1BP
- SSH3BP
- SSH3BP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.86 | ||
interacting protein | 0.85 | ||
transcription factor binding site profile | 0.84 | ||
virus perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.28 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.28 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (160)
BRK1
Novelty: 0.02289534
p_int: 0.999999989
p_ni: 1.2e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
NCKAP1
Novelty: 0.03486454
p_int: 0.999999941
p_ni: 6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ABI2
Novelty: 0.02324355
p_int: 0.999999602
p_ni: 3.92e-7
p_wrong: 6e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
NCK2
Novelty: 0.02220251
p_int: 0.999998187
p_ni: 0.000001813
Score: 0.689
Data Source: BioPlex,STRINGDB
IKBIP
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999979814
p_ni: 0.000020186
Data Source: BioPlex
AMZ1
Family: Enzyme
Novelty: 0.246305
p_int: 0.999825181
p_ni: 0.000174816
p_wrong: 4e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
WASF3
Novelty: 0.0248378
p_int: 0.999782665
p_ni: 0.000217323
p_wrong: 1.1e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
TIMM50
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999761331
p_ni: 0.000234237
p_wrong: 0.000004432
Score: 0.305
Data Source: BioPlex,STRINGDB
NCK1
Novelty: 0.00352084
p_int: 0.999594658
p_ni: 0.000405342
Score: 0.972
Data Source: BioPlex,STRINGDB
NHSL2
Novelty: 4.36275023
p_int: 0.999274579
p_ni: 0.000725358
p_wrong: 6.3e-8
Score: 0.633
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (11)
PathwayCommons (9)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate WASPs and WAVEs | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
RHO GTPase Effectors | ||||
RHO GTPases Activate WASPs and WAVEs | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (5)
Components (12)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 0.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 0.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | abl interactor 1 | VGNC:5303 | 450363 | |||||
Macaque | abl interactor 1 | 707698 | ||||||
Mouse | MGI:104913 | 11308 | ||||||
Rat | RGD:621008 | 79249 | ||||||
Dog | abl interactor 1 | VGNC:37474 | 607247 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | abl interactor 1 | |||||
Macaque | abl interactor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | abl interactor 1 | |||||
Publication Statistics
PubMed Score 142.28
PubMed score by year
PubTator Score 99.91
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
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