Tbio ABI1 Abl interactor 1

Protein Summary

Description

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8IZP0
• A9Z1Y6
• B3KX62
• B4DQ58
• H7BXI6
• O15147
• O76049
• O95060
• Q5T2R3
• Q5T2R4
• Q5T2R6
• Q5T2R7
• Q5T2R9
• Q5W070
• Q5W072
• Q8TB63
• Q96S81
• Q9NXZ9
• Q9NYB8

Gene Name

• ABI1

Ensembl ID

• ENST00000346832
• ENSP00000279599
• ENSG00000136754
• ENST00000359188
• ENSP00000352114
• ENST00000376137
• ENSP00000365307
• ENST00000376138
• ENSP00000365308
• ENST00000376139
• ENSP00000365309
• ENST00000376140
• ENSP00000365310
• ENST00000376142
• ENSP00000365312
• ENST00000376166
• ENSP00000365336
• ENST00000376170
• ENSP00000365340
• ENST00000490841
• ENSP00000440101

Symbol

• SSH3BP1
• E3B1
• ABI-1
• ABLBP4
• NAP1BP
• SSH3BP
• SSH3BP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.86
interacting protein	0.85
transcription factor binding site profile	0.84
virus perturbation	0.83
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.87   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.87   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0