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Tbio
ABI1
Abl interactor 1

Protein Summary
Description
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin po ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346832
  • ENSP00000279599
  • ENSG00000136754
  • ENST00000359188
  • ENSP00000352114
  • ENST00000376137
  • ENSP00000365307
  • ENST00000376138
  • ENSP00000365308
  • ENST00000376139
  • ENSP00000365309
  • ENST00000376140
  • ENSP00000365310
  • ENST00000376142
  • ENSP00000365312
  • ENST00000376166
  • ENSP00000365336
  • ENST00000376170
  • ENSP00000365340
  • ENST00000490841
  • ENSP00000440101

Symbol
  • SSH3BP1
  • E3B1
  • ABI-1
  • ABLBP4
  • NAP1BP
  • SSH3BP
  • SSH3BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
interacting protein
0.85
transcription factor binding site profile
0.84
virus perturbation
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.87   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.87   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0