Tbio ABI1 Abl interactor 1

Protein Summary

Description

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8IZP0
• A9Z1Y6
• B3KX62
• B4DQ58
• H7BXI6
• O15147
• O76049
• O95060
• Q5T2R3
• Q5T2R4
• Q5T2R6
• Q5T2R7
• Q5T2R9
• Q5W070
• Q5W072
• Q8TB63
• Q96S81
• Q9NXZ9
• Q9NYB8

Gene Name

• ABI1

Ensembl ID

• ENST00000346832
• ENSP00000279599
• ENSG00000136754
• ENST00000359188
• ENSP00000352114
• ENST00000376137
• ENSP00000365307
• ENST00000376138
• ENSP00000365308
• ENST00000376139
• ENSP00000365309
• ENST00000376140
• ENSP00000365310
• ENST00000376142
• ENSP00000365312
• ENST00000376166
• ENSP00000365336
• ENST00000376170
• ENSP00000365340
• ENST00000490841
• ENSP00000440101

Symbol

• SSH3BP1
• E3B1
• ABI-1
• ABLBP4
• NAP1BP
• SSH3BP
• SSH3BP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.86
interacting protein	0.85
transcription factor binding site profile	0.84
virus perturbation	0.83
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.28   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.28   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (160)

Explore Interacting Targets

1 – 10 of 160

• See Interactions on String-DB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999999989

p_ni:  1.2e-8

Score:  0.988

Data Source:  BioPlex,STRINGDB

NCKAP1

Tbio

Novelty:  0.03486454

p_int:  0.999999941

p_ni:  6e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

ABI2

Tbio

Novelty:  0.02324355

p_int:  0.999999602

p_ni:  3.92e-7

p_wrong:  6e-9

Score:  0.981

Data Source:  BioPlex,STRINGDB

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999998187

p_ni:  0.000001813

Score:  0.689

Data Source:  BioPlex,STRINGDB

IKBIP

Tbio

Family:  Enzyme

Novelty:  0.18707639

p_int:  0.999979814

p_ni:  0.000020186

Data Source:  BioPlex

AMZ1

Tdark

Family:  Enzyme

Novelty:  0.246305

p_int:  0.999825181

p_ni:  0.000174816

p_wrong:  4e-9

Score:  0.313

Data Source:  BioPlex,STRINGDB

WASF3

Tbio

Novelty:  0.0248378

p_int:  0.999782665

p_ni:  0.000217323

p_wrong:  1.1e-8

Score:  0.99

Data Source:  BioPlex,STRINGDB

TIMM50

Tbio

Family:  Enzyme

Novelty:  0.0238053

p_int:  0.999761331

p_ni:  0.000234237

p_wrong:  0.000004432

Score:  0.305

Data Source:  BioPlex,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999594658

p_ni:  0.000405342

Score:  0.972

Data Source:  BioPlex,STRINGDB

NHSL2

Tdark

Novelty:  4.36275023

p_int:  0.999274579

p_ni:  0.000725358

p_wrong:  6.3e-8

Score:  0.633

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (11)

PathwayCommons (9)

WikiPathways (1)

Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Name	Explore in Pharos	Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (5)

Components (12)

Processes (11)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
SH3 domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
cytoskeletal protein binding	Traceable Author Statement (TAS)	ProtInc
protein tyrosine kinase activator activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	1	1	0	1.1	0.9

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	0	1.1	0.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell junction
Cell membrane
Cell projection
Chromosomal rearrangement
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
ulcerative colitis

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	abl interactor 1	VGNC:5303	450363
Macaque	abl interactor 1		707698
Mouse	abl-interactor 1	MGI:104913	11308
Rat	abl-interactor 1	RGD:621008	79249
Dog	abl interactor 1	VGNC:37474	607247

Species	Name	OMA	EggNOG	Inparanoid
Chimp	abl interactor 1
Macaque	abl interactor 1
Mouse	abl-interactor 1
Rat	abl-interactor 1
Dog	abl interactor 1

Publication Statistics

PubMed Score 142.28

PubMed score by year

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PubTator Score 99.91

PubTator score by year

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Related Publications

Text Mined References (73)

GeneRif Annotations (40)

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10

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PMID	Year	Title