Tchem ABHD6 Monoacylglycerol lipase ABHD6

Protein Summary

Description

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).

Uniprot Accession IDs

• Q9BV23
• B2R7Y9
• Q6ZMF7

Gene Name

• ABHD6

Ensembl ID

• ENST00000295962
• ENSP00000295962
• ENSG00000163686
• ENST00000478253
• ENSP00000420315

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
histone modification site profile	0.85
transcription factor binding site profile	0.76
cellular component	0.75
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Monoacylglycerol Lipase Abhd6

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Monoacylglycerol Lipase Abhd6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.25   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.25   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1