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Tchem
ABHD6
Monoacylglycerol lipase ABHD6

Protein Summary
Description
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295962
  • ENSP00000295962
  • ENSG00000163686
  • ENST00000478253
  • ENSP00000420315
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.85
transcription factor binding site profile
0.76
cellular component
0.75
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.25   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.25   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1