You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ABHD4
Protein ABHD4

Protein Summary
Description
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418446
  • ENSP00000388751
  • ENSG00000100439
  • ENST00000428304
  • ENSP00000414558

Symbol
  • ABH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
small molecule perturbation
0.85
disease
0.84
disease perturbation
0.83
metabolite
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
GDE1
Tbio
Family:  Enzyme
Novelty:  0.05854843
Score:  0.839
Data Source:  STRINGDB
NAPEPLD
Tchem
Family:  Enzyme
Novelty:  0.00755191
Score:  0.82
Data Source:  STRINGDB
FAAH2
Tchem
Family:  Enzyme
Novelty:  0.06197067
Score:  0.743
Data Source:  STRINGDB
PTPN22
Tchem
Family:  Enzyme
Novelty:  0.00168847
Score:  0.716
Data Source:  STRINGDB
ABHD12
Tchem
Family:  Enzyme
Novelty:  0.02587535
Score:  0.708
Data Source:  STRINGDB
FAAH
Tchem
Family:  Enzyme
Novelty:  0.00162361
Score:  0.702
Data Source:  STRINGDB
ABHD6
Tchem
Family:  Enzyme
Novelty:  0.019314
Score:  0.691
Data Source:  STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
Score:  0.668
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.657
Data Source:  STRINGDB
TOX4
Tbio
Family:  TF
Novelty:  0.02486844
Score:  0.618
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Acyl chain remodelling of PE (R-HSA-1482839)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PE
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PE
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
narcolepsy-cataplexy syndrome
4
1
0
1.7
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
narcolepsy-cataplexy syndrome
0
1.7
73.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 4
452784
Macaque
abhydrolase domain containing 4
711758
Mouse
MGI:1915938
105501
Rat
RGD:1311858
364380
Dog
abhydrolase domain containing 4
VGNC:37470
607421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 4
Macaque
abhydrolase domain containing 4
Mouse
Rat
Dog
abhydrolase domain containing 4
Publication Statistics
PubMed Score 11.10
PubMed score by year
PubTator Score 2.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title