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Tbio
ABHD3
Phospholipase ABHD3

Protein Summary
Description
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289119
  • ENSP00000289119
  • ENSG00000158201
  • ENST00000577891
  • ENSP00000463365

Symbol
  • LABH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.8
virus perturbation
0.68
small molecule perturbation
0.64
histone modification site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.906433389
p_ni:  0.093505893
p_wrong:  0.000060718
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.896280781
p_ni:  0.103718911
p_wrong:  3.08e-7
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.888996402
p_ni:  0.111003592
p_wrong:  6e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.803009089
p_ni:  0.196990911
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.783811688
p_ni:  0.21618831
p_wrong:  2e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
CABLES1
Tbio
Novelty:  0.04822454
Score:  0.766
Data Source:  STRINGDB
OSBPL1A
Tbio
Novelty:  0.12951159
Score:  0.729
Data Source:  STRINGDB
CABLES2
Tbio
Novelty:  0.35458236
Score:  0.718
Data Source:  STRINGDB
THOC1
Tbio
Novelty:  0.03702557
Score:  0.693
Data Source:  STRINGDB
IAH1
Tbio
Family:  Enzyme
Novelty:  0.10541696
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylcholine measurement
3
9
8
6.8
86.8
mean corpuscular volume
1
1
1
34.6
phosphatidylcholine 32:2 measurement
1
1
1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylcholine measurement
8
6.8
86.8
mean corpuscular volume
1
34.6
phosphatidylcholine 32:2 measurement
1
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 3
VGNC:5136
455330
Macaque
abhydrolase domain containing 3
701145
Mouse
MGI:2147183
106861
Rat
RGD:1310655
291793
Dog
abhydrolase domain containing 3
VGNC:37469
480177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 3
Macaque
abhydrolase domain containing 3
Mouse
Rat
Dog
abhydrolase domain containing 3
Publication Statistics
PubMed Score 4.24
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title