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Tbio
ABHD17A
Alpha/beta hydrolase domain-containing protein 17A

Protein Summary
Description
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250974
  • ENSP00000250974
  • ENSG00000129968
  • ENST00000292577
  • ENSP00000292577

Symbol
  • C19orf27
  • FAM108A1
  • C19orf27
  • FAM108A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
kinase perturbation
0.71
cell line
0.62
transcription factor
0.62
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.999980785
p_ni:  0.000019194
p_wrong:  2.1e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.999901751
p_ni:  0.000007206
p_wrong:  0.000091043
Score:  0.545
Data Source:  BioPlex,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.980493253
p_ni:  0.019506699
p_wrong:  4.8e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
p_int:  0.928503848
p_ni:  0.000086308
p_wrong:  0.071409845
Score:  0.175
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.760645532
p_ni:  0.000363504
p_wrong:  0.238990965
Data Source:  BioPlex
REXO1
Tdark
Family:  Enzyme
Novelty:  0.23817911
Score:  0.748
Data Source:  STRINGDB
SCAMP4
Tdark
Novelty:  0.20081295
Score:  0.737
Data Source:  STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
Score:  0.731
Data Source:  STRINGDB
DUS3L
Tdark
Family:  Enzyme
Novelty:  0.24952542
Score:  0.73
Data Source:  STRINGDB
LYPLAL1
Tbio
Family:  Enzyme
Novelty:  0.0447394
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
95.4
mean reticulocyte volume
1
2
2
95
mean corpuscular hemoglobin concentration
1
1
1
86.4
body mass index
3
3
4
82.3
reticulocyte measurement
3
1
3
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
95.4
mean reticulocyte volume
2
95
mean corpuscular hemoglobin concentration
1
86.4
body mass index
4
82.3
reticulocyte measurement
3
78.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 17A
743474
Macaque
abhydrolase domain containing 17A
709119
Mouse
MGI:106388
216169
Rat
RGD:1359682
299617
Dog
abhydrolase domain containing 17A
VGNC:37465
485076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 17A
Macaque
abhydrolase domain containing 17A
Mouse
Rat
Dog
abhydrolase domain containing 17A
Publication Statistics
PubMed Score 3.54
PubMed score by year
PubTator Score 1.27
PubTator score by year
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Related Publications
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PMID
Year
Title