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Tbio
ABHD10
Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Protein Summary
Description
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate. This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273359
  • ENSP00000273359
  • ENSG00000144827
  • ENST00000494817
  • ENSP00000418973
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
histone modification site profile
0.67
tissue sample
0.61
kinase perturbation
0.6
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.999993548
p_ni:  0.000006453
Data Source:  BioPlex
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.999773878
p_ni:  0.000226122
Score:  0.36
Data Source:  BioPlex,STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.885373131
p_ni:  0.114626869
Score:  0.33
Data Source:  BioPlex,STRINGDB
ABHD13
Tdark
Family:  Enzyme
Novelty:  2.01646617
Score:  0.69
Data Source:  STRINGDB
ABHD12B
Tdark
Family:  Enzyme
Novelty:  0.74329172
Score:  0.603
Data Source:  STRINGDB
ABHD3
Tbio
Family:  Enzyme
Novelty:  0.24877871
Score:  0.602
Data Source:  STRINGDB
ABHD16B
Tdark
Family:  Enzyme
Novelty:  1.75722584
Score:  0.592
Data Source:  STRINGDB
ABHD16A
Tchem
Family:  Enzyme
Novelty:  0.04797219
Score:  0.584
Data Source:  STRINGDB
LDAH
Tbio
Family:  Enzyme
Novelty:  0.0951829
Score:  0.581
Data Source:  STRINGDB
TEX30
Tdark
Novelty:  0.69754742
Score:  0.557
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
48
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 10
VGNC:1726
743016
Macaque
abhydrolase domain containing 10
707464
Mouse
MGI:2442422
213012
Rat
RGD:1308084
303953
Dog
abhydrolase domain containing 10
478561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 10
Macaque
abhydrolase domain containing 10
Mouse
Rat
Dog
abhydrolase domain containing 10
Publication Statistics
PubMed Score 5.93
PubMed score by year
PubTator Score 5.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title