Tbio ABCF3 ATP-binding cassette sub-family F member 3

Protein Summary

Description

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q9NUQ8
• A8K241
• Q86UA2
• Q8NAN1
• Q96GS8
• Q9H7A8

Gene Name

• ABCF3

Ensembl ID

• ENST00000292808
• ENSP00000292808
• ENSG00000161204
• ENST00000429586
• ENSP00000411471

Symbol

• EST201864

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
molecular function	0.91
disease perturbation	0.79
kinase perturbation	0.71
transcription factor binding site profile	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family F Member 3

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Atp-binding Cassette Sub-family F Member 3

Protein / Hydrolase / Atp-binding Cassette Sub-family F Member 3

DTO Classes

Protein / Enzyme / Hydrolase / Atp-binding Cassette Sub-family F Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.22   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.22   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0