You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ABCE1
ATP-binding cassette sub-family E member 1

Protein Summary
Description
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296577
  • ENSP00000296577
  • ENSG00000164163

Symbol
  • RLI
  • RNASEL1
  • RNASELI
  • RNS4I
  • RLI
  • OABP
  • RLI1
  • ABC38
  • RNS4I
  • RNASEL1
  • RNASELI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.97
kinase perturbation
0.96
molecular function
0.96
interacting protein
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.61   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.61   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0