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Tbio
ABCD2
ATP-binding cassette sub-family D member 2

Protein Summary
Description
Probable transporter. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308666
  • ENSP00000310688
  • ENSG00000173208

Symbol
  • ALD1
  • ALDL1
  • ALDR
  • ALDRP
  • ALDR
  • ABC39
  • ALDL1
  • ALDRP
  • hALDR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.75
histone modification site profile
0.75
protein domain
0.73
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.95   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.95   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
PEX19
Tbio
Novelty:  0.00605342
Score:  0.976
Data Source:  Reactome,STRINGDB
PEX3
Tbio
Novelty:  0.01171119
Score:  0.963
Data Source:  Reactome,STRINGDB
ABCD3
Tbio
Family:  Transporter
Novelty:  0.01081462
Score:  0.946
Data Source:  Reactome,STRINGDB
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
Score:  0.944
Data Source:  Reactome,STRINGDB
ACSBG1
Tbio
Family:  Enzyme
Novelty:  0.00381436
Score:  0.9
Data Source:  STRINGDB
SLC25A17
Tbio
Family:  Transporter
Novelty:  0.00601179
Score:  0.838
Data Source:  STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
Score:  0.773
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.75
Data Source:  STRINGDB
ACSL6
Tbio
Family:  Enzyme
Novelty:  0.0100317
Score:  0.687
Data Source:  STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Class I peroxisomal membrane protein import
Protein localization
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily D member 2
VGNC:4912
466952
Macaque
ATP binding cassette subfamily D member 2
697556
Mouse
MGI:1349467
26874
Rat
RGD:69244
84356
Dog
ATP binding cassette subfamily D member 2
VGNC:37446
477643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily D member 2
Macaque
ATP binding cassette subfamily D member 2
Mouse
Rat
Dog
ATP binding cassette subfamily D member 2
Publication Statistics
PubMed Score 76.95
PubMed score by year
PubTator Score 211.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title