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Tbio
ABCD1
ATP-binding cassette sub-family D member 1

Protein Summary
Description
Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (PubMed:15682271, PubMed:11248239, PubMed:16946495). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). The protein encoded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218104
  • ENSP00000218104
  • ENSG00000101986

Symbol
  • ALD
  • ALD
  • AMN
  • ALDP
  • ABC42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
virus perturbation
0.85
histone modification site profile
0.77
cellular component
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.6   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 373   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.6   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 373   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.99998463
p_ni:  0.00001537
Score:  0.242
Data Source:  BioPlex,STRINGDB
VASN
Tbio
Novelty:  0.05424159
p_int:  0.999979761
p_ni:  0.000020238
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999874741
p_ni:  0.000125258
p_wrong:  2e-9
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.999815311
p_ni:  0.000183731
p_wrong:  9.58e-7
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99911507
p_ni:  0.000847755
p_wrong:  0.000037175
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.999055897
p_ni:  0.000944103
p_wrong:  1e-9
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.997047677
p_ni:  0.002932232
p_wrong:  0.000020091
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.996502309
p_ni:  0.003412851
p_wrong:  0.00008484
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.992467418
p_ni:  0.007479343
p_wrong:  0.000053239
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.991163481
p_ni:  0.008718692
p_wrong:  0.000117827
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Class I peroxisomal membrane protein import
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Beta-oxidation of very long chain fatty acids
Class I peroxisomal membrane protein import
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Genetic Interaction (IGI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
2
2
87
4
2
0
1.2
87
hemoglobin measurement
1
1
1
29.9
hematocrit
1
1
1
29
body mass index
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
87
0
1.2
87
hemoglobin measurement
1
29.9
hematocrit
1
29
body mass index
1
10
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily D member 1
696794
Mouse
MGI:1349215
11666
Rat
RGD:1562128
363516
Dog
ATP binding cassette subfamily D member 1
VGNC:37445
612520
Horse
ATP binding cassette subfamily D member 1
VGNC:14923
100058868
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily D member 1
Mouse
Rat
Dog
ATP binding cassette subfamily D member 1
Horse
ATP binding cassette subfamily D member 1
Publication Statistics
PubMed Score 174.60
PubMed score by year
PubTator Score 275.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title