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Tclin
ABCC8
ATP-binding cassette sub-family C member 8

Protein Summary
Description
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302539
  • ENSP00000303960
  • ENSG00000006071
  • ENST00000389817
  • ENSP00000374467
  • ENST00000612903
  • ENSP00000483031
  • ENST00000643878
  • ENSP00000495271
  • ENST00000644542
  • ENSP00000495532

Symbol
  • HRINS
  • SUR
  • SUR1
  • HI
  • SUR
  • HHF1
  • MRP8
  • PHHI
  • SUR1
  • ABC36
  • HRINS
  • TNDM2
  • SUR1delta2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
co-expressed gene
0.99
protein domain
0.92
phenotype
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1269.12   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1269.12   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
glibenclamide
Rendered image for glibenclamide
diazoxide
Rendered image for diazoxide
glimepiride
Rendered image for glimepiride
nateglinide
Rendered image for nateglinide
repaglinide
Rendered image for repaglinide
tolazamide
Rendered image for tolazamide
carbutamide
Rendered image for carbutamide
chlorpropamide
Rendered image for chlorpropamide
glibornuride
Rendered image for glibornuride
gliclazide
Rendered image for gliclazide
Protein-Protein Interactions (126)
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
Score:  0.998
Data Source:  Reactome,STRINGDB
KCNJ8
Tbio
Family:  IC
Novelty:  0.00369886
Score:  0.995
Data Source:  Reactome,STRINGDB
RAPGEF4
Tchem
Novelty:  0.00235788
Score:  0.983
Data Source:  STRINGDB
RAPGEF3
Tchem
Novelty:  0.00199705
Score:  0.962
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.91
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.905
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.902
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.805
Data Source:  STRINGDB
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
Score:  0.802
Data Source:  STRINGDB
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ATP sensitive Potassium channels
Reactome
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ATP sensitive Potassium channels
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
6
2
1.1
97.8
myeloperoxidase measurement
1
1
1
78.6
BMI-adjusted hip circumference
1
1
1
62.8
BMI-adjusted waist circumference
2
3
3
55.1
sex hormone-binding globulin measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
97.8
myeloperoxidase measurement
1
78.6
BMI-adjusted hip circumference
1
62.8
BMI-adjusted waist circumference
3
55.1
sex hormone-binding globulin measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 8
VGNC:11253
451056
Macaque
ATP binding cassette subfamily C member 8
654490
Mouse
MGI:1352629
20927
Rat
RGD:3786
25559
Dog
ATP binding cassette subfamily C member 8
VGNC:37443
485402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 8
Macaque
ATP binding cassette subfamily C member 8
Mouse
Rat
Dog
ATP binding cassette subfamily C member 8
Publication Statistics
PubMed Score 1269.12
PubMed score by year
PubTator Score 805.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title