Tclin ABCC8 ATP-binding cassette sub-family C member 8

Protein Summary

Description

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• Q09428
• A6NMX8
• E3UYX6
• O75948
• Q16583

Gene Name

• ABCC8

Ensembl ID

• ENST00000302539
• ENSP00000303960
• ENSG00000006071
• ENST00000389817
• ENSP00000374467
• ENST00000612903
• ENSP00000483031
• ENST00000643878
• ENSP00000495271
• ENST00000644542
• ENSP00000495532

Symbol

• HRINS
• SUR
• SUR1
• HI
• SUR
• HHF1
• MRP8
• PHHI
• SUR1
• ABC36
• HRINS
• TNDM2
• SUR1delta2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
co-expressed gene	0.99
protein domain	0.92
phenotype	0.76

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family C Member 8

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Atp-binding Cassette Sub-family C Member 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.92   (req: < 5)

Gene RIFs: 214   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.92   (req: >= 5)

Gene RIFs: 214   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16