Tbio ABCC6 Multidrug resistance-associated protein 6

Protein Summary

Description

Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95255
• A2RRN8
• A8KIG6
• A8Y988
• E7ESW8
• P78420
• Q8TCY8
• Q9UMZ7

Gene Name

• ABCC6

Ensembl ID

• ENST00000205557
• ENSP00000205557
• ENSG00000091262
• ENST00000456970
• ENSP00000405002
• ENST00000575728
• ENSP00000461686
• ENST00000600761
• ENSP00000481979
• ENSG00000275331
• ENST00000622290
• ENSP00000483331

Symbol

• ARA
• MRP6
• ARA
• PXE
• MLP1
• MRP6
• PXE1
• URG7
• ABC34
• GACI2
• MOATE
• MOAT-E
• EST349056

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
protein domain	0.92
disease	0.71
biological term	0.69
gene perturbation	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Multidrug Resistance-associated Protein 6

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Multidrug Resistance-associated Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.87   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.87   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0