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Tchem
ABCC5
Multidrug resistance-associated protein 5

Protein Summary
Description
Acts as a multispecific organic anion pump which can transport nucleotide analogs. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265586
  • ENSP00000265586
  • ENSG00000114770
  • ENST00000334444
  • ENSP00000333926
  • ENST00000382494
  • ENSP00000371934
  • ENST00000392579
  • ENSP00000376358
  • ENST00000443376
  • ENSP00000416840

Symbol
  • MRP5
  • MRP5
  • SMRP
  • ABC33
  • MOATC
  • MOAT-C
  • pABC11
  • EST277145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.98
disease perturbation
0.95
transcription factor binding site profile
0.94
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.36   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.36   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1