Tbio ABCC3 Canalicular multispecific organic anion transporter 2

Protein Summary

Description

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15438
• B2RPA9
• D3DTX9
• O60265
• O60922
• O75621
• O95078
• O95289
• O95290
• Q86X85
• Q9UN52

Gene Name

• ABCC3

Ensembl ID

• ENST00000285238
• ENSP00000285238
• ENSG00000108846
• ENST00000427699
• ENSP00000395160
• ENST00000502426
• ENSP00000427073
• ENST00000505699
• ENSP00000427521

Symbol

• CMOAT2
• MLP2
• MRP3
• MLP2
• MRP3
• ABC31
• MOAT-D
• cMOAT2
• EST90757

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
molecular function	0.99
drug	0.92
protein domain	0.92
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Canalicular Multispecific Organic Anion Transporter 2

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Canalicular Multispecific Organic Anion Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 421.55   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 421.55   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0