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Tbio
ABCB9
ATP-binding cassette sub-family B member 9

Protein Summary
Description
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280560
  • ENSP00000280560
  • ENSG00000150967
  • ENST00000344275
  • ENSP00000456813
  • ENST00000346530
  • ENSP00000280559
  • ENST00000392439
  • ENSP00000376234
  • ENST00000442833
  • ENSP00000456375
  • ENST00000540285
  • ENSP00000441734
  • ENST00000542678
  • ENSP00000440288

Symbol
  • KIAA1520
  • TAPL
  • EST122234
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
co-expressed gene
0.91
cellular component
0.86
protein domain
0.85
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0