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Tbio
ABCB10
ATP-binding cassette sub-family B member 10, mitochondrial

Protein Summary
Description
May mediate critical mitochondrial transport functions related to heme biosynthesis. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344517
  • ENSP00000355637
  • ENSG00000135776

Symbol
  • M-ABC2
  • MTABC2
  • EST20237
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.99
protein domain
0.85
virus perturbation
0.85
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.46   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.46   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.999996175
p_ni:  0.000003825
Data Source:  BioPlex
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.999478502
p_ni:  0.000521498
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.999385318
p_ni:  0.000614682
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999325248
p_ni:  0.000674752
Score:  0.158
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999263312
p_ni:  0.000736688
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999222171
p_ni:  0.000777829
Score:  0.163
Data Source:  BioPlex,STRINGDB
SGSM1
Tbio
Novelty:  0.27948733
p_int:  0.991801764
p_ni:  0.008198236
Data Source:  BioPlex
SLC24A5
Tbio
Family:  Transporter
Novelty:  0.01224635
p_int:  0.989736473
p_ni:  0.010263526
p_wrong:  1e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.987788672
p_ni:  0.012211328
Data Source:  BioPlex
SNX4
Tbio
Novelty:  0.05441145
p_int:  0.984496356
p_ni:  0.015503644
Score:  0.261
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ABC-family proteins mediated transport (R-HSA-382556)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Mitochondrial ABC transporters
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Mitochondrial ABC transporters
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
3
1.1
84.5
mean corpuscular volume
1
1
1
76.8
mean reticulocyte volume
1
1
1
73.2
mean corpuscular hemoglobin concentration
1
1
1
71.9
eosinophil count
2
2
2
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
84.5
mean corpuscular volume
1
76.8
mean reticulocyte volume
1
73.2
mean corpuscular hemoglobin concentration
1
71.9
eosinophil count
2
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 10
VGNC:10527
469706
Macaque
ATP binding cassette subfamily B member 10
574117
Mouse
MGI:1860508
56199
Rat
RGD:1311222
361439
Dog
ATP binding cassette subfamily B member 10
VGNC:37432
100682973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 10
Macaque
ATP binding cassette subfamily B member 10
Mouse
Rat
Dog
ATP binding cassette subfamily B member 10
Publication Statistics
PubMed Score 317.46
PubMed score by year
PubTator Score 15.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title